亲脂性阳离子对分离的大鼠肝细胞中硫胺素转运系统的影响。
Effect of lipophilic cations on thiamine transport system in isolated rat hepatocytes.
作者信息
Yoshioka K, Nishimura H
出版信息
Experientia. 1986 Sep 15;42(9):1022-3. doi: 10.1007/BF01940715.
The effect of lipophilic cations such as triphenylmethylphosphonium, tetraphenylphosphonium and tetraphenylarsonium in addition to dibenzyldimethylammonium on thiamine transport in isolated rat hepatocytes was studied. Lipophilic cations at the concentration 10 microM almost completely inhibited thiamine uptake. Kinetic studies showed that these compounds were competitive inhibitors with a very high affinity. These results suggest that lipophilic cations in addition to quaternary ammonium compounds also share a common binding site for thiamine in isolated rat hepatocytes.
研究了三苯甲基鏻、四苯鏻、四苯胂等亲脂性阳离子以及二苄基二甲基铵对离体大鼠肝细胞中硫胺素转运的影响。浓度为10微摩尔的亲脂性阳离子几乎完全抑制了硫胺素的摄取。动力学研究表明，这些化合物是具有非常高亲和力的竞争性抑制剂。这些结果表明，除季铵化合物外，亲脂性阳离子在离体大鼠肝细胞中也共享硫胺素的一个共同结合位点。
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