Thorlacius-Ussing O, Rasmussen B L
Exp Mol Pathol. 1986 Aug;45(1):59-67. doi: 10.1016/0014-4800(86)90006-7.
A histochemical study was performed to determine the cellular localization of selenium in the adrenals from rats exposed to sodium selenite, as these organs were known to obtain the highest concentration in the rats. Male rats were treated either with 1-15 mg of sodium selenite for 14 days to 6 months in the drinking water, or with 1-20 mg as intraperitoneal injections. Selenium was shown to accumulate in both norepinephrenic and epinephrenic cells in a dose-dependent fashion. After oral exposure most deposits were found in the epinephrenic cells, whereas the norepinephrenic cells contained most in the injected animals. Fourteen days after a single injection (4 mg/kg), deposits could still be observed in the granules of the chromaffin cells. At the ultrastructural level, accumulations were primarily found in the chromaffin granules and to a lesser extent in the lysosomes. Selenium may possibly form bonds to endogenous zinc in the adrenals as has been suggested for the brain.
进行了一项组织化学研究，以确定暴露于亚硒酸钠的大鼠肾上腺中硒的细胞定位，因为已知这些器官在大鼠体内浓度最高。雄性大鼠通过在饮用水中给予1-15毫克亚硒酸钠处理14天至6个月，或通过腹腔注射给予1-20毫克。结果显示，硒以剂量依赖的方式在去甲肾上腺素能细胞和肾上腺素能细胞中积累。口服暴露后，大部分沉积物见于肾上腺素能细胞，而注射给药的动物中，去甲肾上腺素能细胞含硒最多。单次注射（4毫克/千克）14天后，仍可在嗜铬细胞的颗粒中观察到沉积物。在超微结构水平上，积累主要见于嗜铬颗粒，在溶酶体中较少。正如对脑的推测一样，硒可能在肾上腺中与内源性锌形成键。
