Vijayakumar Gowtham, Rangasamy Ajai, Kumar Dhilipan, Varadharajan Ramesh, Ramalingam Gunaseelan
Department of Emergency Medicine and Trauma, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India.
Department of Anesthesiology and Critical Care, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India.
J Emerg Trauma Shock. 2023 Apr-Jun;16(2):66-67. doi: 10.4103/jets.jets_96_22. Epub 2023 Feb 24.
Aluminum phosphide (ALP) is one of the most commonly used pesticides worldwide with high mortality rates primarily due to the production of phosphene gas which causes severe mitochondrial damage leading to refractory myocardial depression, refractory hypotension, severe metabolic acidosis, and acute respiratory distress syndrome.[1] There is no antidote for ALP poisoning and treatment remains mainly supportive. The available literature shows a favorable outcome with extracorporeal membrane oxygenation (ECMO) in severely intoxicated patients presenting early with cardiovascular collapse. In this study, we describe an adult male who presented to us with ALP poisoning following deliberate self-harm, was put on ECMO in the emergency room and had a good prognosis.
磷化铝(ALP)是全球最常用的杀虫剂之一,死亡率很高,主要是因为它会产生磷化氢气体,这种气体可导致严重的线粒体损伤,进而引发难治性心肌抑制、难治性低血压、严重代谢性酸中毒和急性呼吸窘迫综合征。[1] 目前尚无针对磷化铝中毒的解毒剂,治疗仍主要以支持治疗为主。现有文献表明,对于早期出现心血管衰竭的重度中毒患者,体外膜肺氧合(ECMO)治疗效果良好。在本研究中,我们描述了一名成年男性,他因故意自残而出现磷化铝中毒,在急诊室接受了ECMO治疗,预后良好。