首例携带t(7;12)(q36;p17)的婴儿急性髓系白血病小鼠模型 - Suppr

Suppr

超能文献

First mouse model of infant acute myeloid leukemia with t(7;12)(q36;p17).

作者信息

Jevtic Zivojin, Schwaller Juerg

机构信息

University Children Hospital Basel, Department of Biomedicine, University of Basel.

出版信息

Haematologica. 2024 Mar 1;109(3):712-714. doi: 10.3324/haematol.2023.283659.

DOI:10.3324/haematol.2023.283659

PMID:37584296

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10905090/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4a9/10905090/f3935841ef75/109712.fig1.jpg

相似文献

First mouse model of infant acute myeloid leukemia with t(7;12)(q36;p17).首例携带t(7;12)(q36;p17)的婴儿急性髓系白血病小鼠模型

Haematologica. 2024 Mar 1;109(3):712-714. doi: 10.3324/haematol.2023.283659.

Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation.异常 MNX1 表达与 t(7;12)(q36;p13) 儿童急性髓系白血病相关，通过改变组蛋白甲基化诱导疾病。

Haematologica. 2024 Mar 1;109(3):725-739. doi: 10.3324/haematol.2022.282255.

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature.伴有 t(7;12)(q36;p13)的急性髓系白血病（AML）与婴儿期和 19 号染色体三体有关：来自北欧儿科血液学和肿瘤学会（NOPHO-AML）的数据和文献复习。

Genes Chromosomes Cancer. 2018 Jul;57(7):359-365. doi: 10.1002/gcc.22538. Epub 2018 Apr 30.

[Advances in the mouse models of myeloid leukemia].[髓系白血病小鼠模型的研究进展]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2019 Oct 25;36(5):885-892. doi: 10.7507/1001-5515.201903012.

Three-way complex translocations in infant acute myeloid leukemia with t(7;12)(q36;p13): the incidence and correlation of a HLXB9 overexpression.伴有t(7;12)(q36;p13)的婴儿急性髓系白血病中的三向复杂易位：HLXB9过表达的发生率及相关性

Cancer Genet Cytogenet. 2009 Jun;191(2):102-5. doi: 10.1016/j.cancergencyto.2009.02.007.

Acute myeloid leukemia with a novel (7;11)(q36;q13) translocation.伴有新型（7；11）（q36；q13）易位的急性髓系白血病

Cancer Genet Cytogenet. 1998 May;103(1):71-2. doi: 10.1016/s0165-4608(97)00359-2.

t(7;12)(q36;p13) and t(7;12)(q32;p13)--translocations involving ETV6 in children 18 months of age or younger with myeloid disorders.t(7;12)(q36;p13)和t(7;12)(q32;p13)——18个月及以下患有骨髓疾病儿童中涉及ETV6的易位。

Leukemia. 2001 Jun;15(6):915-20. doi: 10.1038/sj.leu.2402121.

A Novel and Cytogenetically Cryptic t(7;21)(q36.1;q22) Disrupting RUNX1 in Acute Myeloid Leukemia.一种新型且细胞遗传学隐匿的t(7;21)(q36.1;q22)，其在急性髓系白血病中破坏RUNX1

Cytogenet Genome Res. 2018;156(3):140-143. doi: 10.1159/000494452. Epub 2018 Nov 16.

Translocation (2;7)(p13;q36) in a case of acute nonlymphocytic leukemia evolving from a myelodysplastic syndrome.一例由骨髓增生异常综合征演变而来的急性非淋巴细胞白血病中的（2；7）（p13；q36）易位

Cancer Genet Cytogenet. 1988 Oct 15;35(2):199-204. doi: 10.1016/0165-4608(88)90241-5.

An induced pluripotent stem cell t(7;12)(q36;p13) acute myeloid leukemia model shows high expression of MNX1 and a block in differentiation of the erythroid and megakaryocytic lineages.诱导多能干细胞 t(7;12)(q36;p13) 急性髓系白血病模型显示 MNX1 高表达，并阻断红系和巨核细胞谱系的分化。

Int J Cancer. 2022 Sep 1;151(5):770-782. doi: 10.1002/ijc.34122. Epub 2022 Jun 3.

本文引用的文献

Haematologica. 2024 Mar 1;109(3):725-739. doi: 10.3324/haematol.2022.282255.

Mechanisms associated with t(7;12) acute myeloid leukaemia: from genetics to potential treatment targets.与 t(7;12) 急性髓系白血病相关的机制：从遗传学角度到潜在的治疗靶点。

Biosci Rep. 2023 Jan 31;43(1). doi: 10.1042/BSR20220489.

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.一种选择性的 WDR5 降解剂可抑制患者来源的小鼠模型中的急性髓系白血病。

Sci Transl Med. 2021 Sep 29;13(613):eabj1578. doi: 10.1126/scitranslmed.abj1578.

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.在融合癌基因驱动的髓系白血病中，造血层次的个体发生变化决定了儿科的特异性和疾病表型。

Cancer Discov. 2019 Dec;9(12):1736-1753. doi: 10.1158/2159-8290.CD-18-1463. Epub 2019 Oct 29.

The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells.同源盒转录因子 HB9 诱导造血干细胞和祖细胞衰老并阻止其分化。

Haematologica. 2019 Jan;104(1):35-46. doi: 10.3324/haematol.2018.189407. Epub 2018 Aug 9.

Nonirradiated NOD,B6.SCID Il2rγ-/- Kit(W41/W41) (NBSGW) mice support multilineage engraftment of human hematopoietic cells.非辐照 NOD,B6.SCID Il2rγ-/- Kit(W41/W41) (NBSGW) 小鼠支持人造血细胞的多谱系植入。

Stem Cell Reports. 2015 Feb 10;4(2):171-80. doi: 10.1016/j.stemcr.2014.12.005. Epub 2015 Jan 15.

Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia.综合分析 I 型和 II 型畸变突出了小儿急性髓系白血病的遗传异质性。

Haematologica. 2011 Oct;96(10):1478-87. doi: 10.3324/haematol.2010.038976. Epub 2011 Jul 26.

Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.蛋氨酸腺苷转移酶 II 作为 Maf 癌蛋白的转录核心抑制因子。

Mol Cell. 2011 Mar 4;41(5):554-66. doi: 10.1016/j.molcel.2011.02.018.

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.Menin结合的全基因组分析为MEN1肿瘤发生提供了见解。

PLoS Genet. 2006 Apr;2(4):e51. doi: 10.1371/journal.pgen.0020051. Epub 2006 Apr 7.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验