Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.
Chair and Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland.
Fundam Clin Pharmacol. 2024 Feb;38(1):33-41. doi: 10.1111/fcp.12947. Epub 2023 Aug 16.
Cannabis, more commonly known as marijuana or hemp, has been used for centuries to treat various conditions. Cannabis contains two main components cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD, unlike THC, is devoid of psychoactive effects and is well tolerated by the human body but has no direct effect on the receptors of the endocannabid system, despite the lack of action on the receptors of the endocannabid system.
We have prepared a literature review based on the latest available literature regarding the analgesic effects of CBD. CBD has a wide range of effects on the human body. In this study, we will present the potential mechanisms responsible for the analgesic effect of CBD. To the best of our knowledge, this is the first review to explore the analgesic mechanisms of CBD.
The analgesic effect of CBD is complex and still being researched. CBD models the perception of pain by acting on G protein-coupled receptors. Another group of receptors that CBD acts on are serotonergic receptors. The effect of CBD on an enzyme of potential importance in the production of inflammatory factors such as cyclooxygenases and lipoxygenases has also been confirmed. The presented potential mechanisms of CBD's analgesic effect are currently being extensively studied.
大麻，通常被称为大麻或麻，已被用于治疗各种疾病已有几个世纪。大麻含有两种主要成分：大麻二酚 (CBD) 和四氢大麻酚 (THC)。与 THC 不同，CBD 没有致幻作用，并且被人体很好地耐受，但对内源性大麻素系统的受体没有直接作用，尽管对该系统的受体没有作用。
我们根据最新的有关 CBD 镇痛作用的可用文献准备了一篇文献综述。 CBD 对人体有广泛的影响。在这项研究中，我们将介绍 CBD 镇痛作用的潜在机制。据我们所知，这是第一篇探讨 CBD 镇痛机制的综述。
CBD 的镇痛作用复杂，仍在研究中。 CBD 通过作用于 G 蛋白偶联受体来模拟疼痛的感知。 CBD 作用于的另一组受体是血清素受体。 CBD 对潜在重要的酶的作用也得到了证实，这种酶在炎症因子如环氧化酶和脂氧合酶的产生中起作用。目前正在广泛研究 CBD 镇痛作用的潜在机制。
