Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Isr Med Assoc J. 2022 Dec 1;25(12):853-854.
Endovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.
经血管内取出的血栓可能是诊断中风病因的潜在资源。这种方法可能会影响二级预防治疗。我们通过对血栓进行连续冲洗来测量洗脱的凝血酶活性。我们得出结论，一种测量在急性中风血管内血栓切除术过程中取出的血栓中凝血酶变化的测定方法可能作为血栓起源的诊断标志物。这些差异的推测机制可能是血栓在取出之前的位置，由于血流高，导致动脉粥样硬化血栓中的凝血酶洗脱，而与之相反，心耳低血流保持高凝血酶水平。
