Department of Pharmacy, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Department of Pharmacy Practice, University of Mississippi, School of Pharmacy, Jackson, Mississippi, USA.
Nutr Clin Pract. 2023 Dec;38(6):1253-1262. doi: 10.1002/ncp.11064. Epub 2023 Aug 16.
Parenteral nutrition (PN) compounding is a complex process that requires knowledge and training to ensure the safety and efficacy of this form of nutrition support therapy. Unfortunately, errors and lack of adherence to safe PN compounding recommendations and sterile compounding requirements have resulted in patient injury and death. These lapses in the safe provision of PN have been the result of various factors, including a lack of understanding of PN compatibility, stability, and sterility requirements, as well as drug product shortages and order entry errors. This review will describe the current challenges with the education and training regarding PN compounding, compatibility and stability of PN admixtures, simultaneous administration of nonnutrient medications with PN admixtures, and specific challenges with special populations such as neonates, pediatrics, and those receiving home care.
肠外营养（PN）配制是一个复杂的过程，需要知识和培训，以确保这种形式的营养支持治疗的安全性和有效性。不幸的是，错误和不遵守安全的 PN 配制建议和无菌配制要求导致了患者的伤害和死亡。这些 PN 安全提供方面的失误是多种因素造成的，包括对 PN 相容性、稳定性和无菌要求的理解不足，以及药物产品短缺和医嘱录入错误。这篇综述将描述当前 PN 配制教育和培训、PN 添加剂的相容性和稳定性、PN 添加剂与非营养药物同时给药以及特殊人群（如新生儿、儿科和接受家庭护理的人群）的具体挑战方面所面临的挑战。
