Yue Jiaqi, Xiao Ying, Chen Wansheng
The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Pharmacy, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Crit Rev Anal Chem. 2024;54(8):3345-3376. doi: 10.1080/10408347.2023.2242953. Epub 2023 Aug 16.
plants, as a kind of medicinal and edible herb, have a long history of application and have been widely concerned by pharmacists and biologists. In this article, the species diversity, taxonomy and distribution, ethnic medicinal records, chemical composition, pharmacological activity, and quality evaluation methods of species were systematically reviewed. In addition, the research progress of plants using biotechnology in recent years was summarized. The phytochemistry and biological activities of are widely evaluated. To date, more than 350 compounds have been isolated from polysaccharides are important functional components and biomarkers. Lobetyolin, atractylenolide III, tangshenoside I, and oligosaccharide can be considered as characteristic index components to evaluate the quality of plants. Although recent experimental evidence has confirmed the pharmacological value of this genus, its quality control, resource development and utilization, and active ingredient synthesis mechanisms are not well studied. In particular, molecular biology research is still in its infancy, but its application prospects are broad, and it is a hot spot for future research on . Therefore, it is urgent to conduct a detailed study on the single level of phytochemistry, pharmacology, and molecular biology of to establish a scientific evaluation system and modern medication guidelines. The multi-angle, multi-level, and multi-aspect integrated association analysis is also an inevitable trend for the future in-depth study of plants. This research status was summarized in order to provide a broader scientific research idea and theoretical reference for the in-depth study of .
作为一种药食两用的草本植物,其应用历史悠久,一直受到药剂师和生物学家的广泛关注。本文系统综述了该植物的物种多样性、分类学与分布、民族药用记载、化学成分、药理活性以及质量评价方法。此外,还总结了近年来利用生物技术对该植物的研究进展。对该植物的植物化学和生物活性进行了广泛评估。迄今为止,已从该植物中分离出350多种化合物,多糖是重要的功能成分和生物标志物。党参炔苷、白术内酯III、党参苷I和低聚糖可被视为评价该植物质量的特征指标成分。尽管最近的实验证据证实了该属的药理价值,但其质量控制、资源开发利用以及活性成分合成机制尚未得到充分研究。特别是分子生物学研究仍处于起步阶段,但其应用前景广阔,是该植物未来研究的热点。因此,迫切需要对该植物在植物化学、药理学和分子生物学的单一水平上进行详细研究,以建立科学的评价体系和现代用药指南。多角度、多层次、多方面的综合关联分析也是该植物未来深入研究的必然趋势。总结这一研究现状,旨在为该植物的深入研究提供更广阔的科研思路和理论参考。