兔呼吸道肺泡区域颗粒清除的测量。

Measurement of particle clearance from the alveolar region of the rabbit respiratory tract.

作者信息

Schlesinger R B, Vollmuth T A, Naumann B D, Driscoll K E

出版信息

Fundam Appl Toxicol. 1986 Aug;7(2):256-63. doi: 10.1016/0272-0590(86)90155-7.

Abstract

This paper describes a method for the measurement of the clearance of inert, insoluble radioactively tagged tracer particles from the alveolar region of the rabbit respiratory tract. The technique uses a fixed detector for noninvasive, external monitoring. Validation of the method is presented, as is the clearance pattern of 3.5-micron latex particles as measured for 56 days postexposure. The clearance of latex deposited within the alveolar region can be described by two phases within this time frame, having half-times of 4.9 and 30.1 days, respectively. Clearance of latex initially deposited on the tracheobronchial tree was essentially complete by 2 days after exposure.

摘要

本文描述了一种测量兔呼吸道肺泡区域惰性、不溶性放射性标记示踪颗粒清除率的方法。该技术使用固定探测器进行无创外部监测。文中介绍了该方法的验证情况，以及暴露后56天测量的3.5微米乳胶颗粒的清除模式。在此时间范围内，肺泡区域内沉积的乳胶清除可分为两个阶段，半衰期分别为4.9天和30.1天。最初沉积在气管支气管树的乳胶在暴露后2天基本清除完毕。