Re T A, Loehr R F, Rodriguez S C, Gilmore C E, Burnett C M
Fundam Appl Toxicol. 1986 Aug;7(2):287-92. doi: 10.1016/0272-0590(86)90158-2.
2-methylresorcinol (2-MR) was administered to groups of 40 male and 35 female Sprague-Dawley rats by admixture with diets at levels of 0.1, 0.4, and 1.5% for periods up to 6 months. Methemoglobin levels were determined after 6 weeks. After 90 days 10 animals/sex/group were killed for clinical pathological and histopathologic determinations. The 25 remaining females and 20 males per group were utilized in teratology and dominant lethal studies presented in Part II (T.A. Re, R.F. Loehr, S.C. Rodriguez, D. E. Rodwell, C.M. Burnett, 1986, Fundam. Appl. Toxicol. 7, 293-298). Ten additional males were killed after 6 months of exposure for additional clinical pathologic determinations and gross pathologic observations. The 20 males/group used in the dominant lethal study (Part II) were also killed after 6 months to serve as a comparison recovery group (gross examination of organs). Feeding 2-MR at a level of 1.5% in the diet was associated with a significant reduction in body weight gains. Females fed at a level of 0.4% also weighed significantly less than the control. No pathological effects were noted after either 90 or 180 days of feeding.
将2-甲基间苯二酚（2-MR）以0.1%、0.4%和1.5%的水平与饲料混合，分别投喂给40只雄性和35只雌性的Sprague-Dawley大鼠，投喂期长达6个月。6周后测定高铁血红蛋白水平。90天后，每组处死10只动物（雌雄各半），进行临床病理学和组织病理学测定。每组剩余的25只雌性和20只雄性大鼠用于第二部分所述的致畸学和显性致死研究（T.A. Re、R.F. Loehr、S.C. Rodriguez、D.E. Rodwell、C.M. Burnett，1986年，《基础与应用毒理学》7卷，第293 - 298页）。暴露6个月后，再处死10只雄性大鼠，进行额外的临床病理学测定和大体病理学观察。用于显性致死研究（第二部分）的每组20只雄性大鼠在6个月后也被处死，作为比较恢复组（进行器官大体检查）。在饲料中添加1.5%的2-MR会导致体重增加显著减少。投喂0.4%水平2-MR的雌性大鼠体重也显著低于对照组。投喂90天和180天后均未观察到病理效应。
