Bonaduce D, Petretta M, Gallo C, Conforti G, Breglio R, Arrichiello P, Arabia F
G Ital Cardiol. 1986 Jun;16(6):465-74.
The relationship between 31 variables and survival after acute myocardial infarction was evaluated in 432 patients discharged from our Coronary Care Unit from 1975 to 1984. The patients were followed for 1 to 105 months and either univariate and multivariate analysis were performed. For end-point death the significant variables (p less than 0.05) selected by the univariate analysis were: age, diabetes, smoke, heart rate at recovery, supraventricular arrhythmias, cardiac failure and complex ventricular arrhythmias either during recovery, either after discharge and finally spontaneous angina after hospital discharge. Meanwhile, for the end-point cardiac death age, smoke and supraventricular arrhythmias were not yet significant while arterial pressure at recovery and effort angina after hospital discharge were. Multivariate analysis identified cardiac failure during recovery, diabetes, complex ventricular arrhythmias before and spontaneous angina after discharge as independent variables contributing to total mortality: effort angina was a further significant one relatively to cardiac death. Thus, our study points out the importance of multivariate survival analysis when evaluating the relationship between survival after discharge for the effect of other prognostic factors. Moreover, providing identification of high risk cohorts permits appropriate interventions designed to lessen risk.
1975年至1984年期间,我们对从冠心病监护病房出院的432例患者进行了31个变量与急性心肌梗死后生存率之间关系的评估。对患者进行了1至105个月的随访,并进行了单因素和多因素分析。对于终点事件死亡,单因素分析选出的显著变量(p<0.05)为:年龄、糖尿病、吸烟、恢复时的心率、室上性心律失常、心力衰竭以及恢复期间、出院后出现的复杂性室性心律失常,最后还有出院后自发性心绞痛。同时,对于终点事件心源性死亡,年龄、吸烟和室上性心律失常尚不显著,而恢复时的动脉压和出院后劳力性心绞痛则显著。多因素分析确定恢复期间的心力衰竭、糖尿病、出院前的复杂性室性心律失常以及出院后的自发性心绞痛是导致总死亡率的独立变量:劳力性心绞痛相对于心源性死亡也是一个显著变量。因此,我们的研究指出了在评估出院后生存率与其他预后因素影响之间的关系时,多因素生存分析的重要性。此外,确定高危人群有助于制定适当的干预措施以降低风险。