Department of Business Administration, Business School, Al al-Bayt University, P.O.BOX 130040, Mafraq 25113, Jordan.
Caspian University, International School of Medicine, Almaty, Kazakhstan.
Pathol Res Pract. 2023 Sep;249:154709. doi: 10.1016/j.prp.2023.154709. Epub 2023 Jul 22.
Human regulatory T cells (Tregs) are essential in pathogenesis of several diseases such as autoimmune diseases and cancers, and their imbalances may be promoting factor in these disorders. The development of the proinflammatory T cell subset TH17 and its balance with the generation of regulatory T cells (Treg) is linked to autoimmune disease and cancers. Long non-coding RNAs (lncRNAs) have recently emerged as powerful regulatory molecules in a variety of diseases and can regulate the expression of significant genes at multiple levels through epigenetic regulation and by modulating transcription, post-transcriptional processes, translation, and protein modification. They may interact with a wide range of molecules, including DNA, RNA, and proteins, and have a complex structural makeup. LncRNAs are implicated in a range of illnesses due to their regulatory impact on a variety of biological processes such as cell proliferation, apoptosis, and differentiation. In this regard, a prominent example is lncRNA NEAT1 which several studies have performed to determine its role in the differentiation of immune cells. Many other lncRNAs have been linked to Treg cell differentiation in the context of immune cell differentiation. In this study, we review recent research on the various roles of lncRNAs in differentiation of Treg cell and regulation of the Th17/Treg balance in autoimmune diseases and tumors in which T regs play an important role.
人类调节性 T 细胞（Tregs）在多种疾病的发病机制中起着至关重要的作用，如自身免疫性疾病和癌症，其失衡可能是这些疾病的促进因素。促炎性 T 细胞亚群 TH17 的发展及其与调节性 T 细胞（Treg）的产生之间的平衡与自身免疫性疾病和癌症有关。长链非编码 RNA（lncRNA）最近作为多种疾病中的强大调节分子出现，可通过表观遗传调控以及调节转录、转录后过程、翻译和蛋白质修饰，在多个水平上调节重要基因的表达。它们可能与多种分子相互作用，包括 DNA、RNA 和蛋白质，并且具有复杂的结构组成。由于它们对多种生物过程（如细胞增殖、凋亡和分化）的调节作用，lncRNA 与多种疾病有关。在这方面，一个突出的例子是 lncRNA NEAT1，有几项研究已经对其在免疫细胞分化中的作用进行了研究。许多其他 lncRNA 与免疫细胞分化过程中的 Treg 细胞分化有关。在这项研究中，我们综述了最近关于 lncRNA 在 Treg 细胞分化和自身免疫性疾病和肿瘤中 Th17/Treg 平衡调节中的各种作用的研究，在这些疾病中 Tregs 发挥着重要作用。
