Department of Psychology, University of California, Davis, Davis, CA 95616, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Department of Psychology, University of California, Davis, Davis, CA 95616, USA.
Psychoneuroendocrinology. 2023 Nov;157:106362. doi: 10.1016/j.psyneuen.2023.106362. Epub 2023 Aug 10.
Social interactions regulate our behavior and physiology, and strong social bonds can buffer us from stress. Coppery titi monkeys (Plecturocebus cupreus) are socially monogamous South American monkeys that display strong social bonds. Infants form selective bonds with their fathers, making them ideal for studying father-daughter bonds. We established a method for quantifying variability in expression of bond-related behaviors in females (n = 12), and the present study is the second to use this method for explaining titi monkey responses to behavioral tests. We also investigated how manipulations of oxytocin (OT) and vasopressin (AVP) influenced juvenile behavior and physiology. Subjects received acute intranasal treatments of saline, low/medium/high OT, low/high AVP, or OT receptor antagonist (OTA) prior to an acute social separation. General linear mixed-effects model results revealed fathers were significant behavioral and physiological stress buffers for their daughters, as evidenced by fewer distress vocalizations (p < 0.001), less locomotion (p < 0.001), and lower plasma cortisol (p < 0.001) in a social separation paradigm. Females vocalized less if they exhibited greater expression of bond-related behaviors with their fathers as infants (p = 0.01), and this stress-buffering effect remained even when the daughter was separated from the father (p = 0.001). While treatments did not alter behaviors, OTA treatment caused the largest rise in plasma cortisol (p < 0.001), suggesting blockade of OT receptors can inhibit fathers' stress-buffering effects. Remarkably, females with greater expression of father-daughter bond-related behaviors exhibited an overall reduced physiological separation distress response (p = 0.04). Findings from the present study advance current knowledge of the neurobiological mechanisms foundational to female bonds and help inform how social disruptions may differently impact individuals based on expression of bond-related behaviors.
社交互动调节着我们的行为和生理机能，而牢固的社会关系可以帮助我们缓解压力。铜色卷尾猴（Plecturocebus cupreus）是一种南美洲的社会性一夫一妻制猴子，它们之间有着强烈的社会联系。幼猴会与父亲形成选择性的联系，这使它们成为研究父女关系的理想选择。我们已经建立了一种方法来量化雌性个体中与关系相关行为的表达变化（n=12），本研究是第二次使用这种方法来解释卷尾猴对行为测试的反应。我们还研究了催产素（OT）和血管升压素（AVP）的操作如何影响青少年的行为和生理机能。在急性社交分离之前，实验对象接受了鼻腔内生理盐水、低/中/高 OT、低/高 AVP 或 OT 受体拮抗剂（OTA）的急性处理。一般线性混合效应模型的结果表明，父亲是女儿重要的行为和生理应激缓冲者，表现在社交分离范式中，女儿的应激叫声较少（p<0.001）、运动较少（p<0.001）、血浆皮质醇水平较低（p<0.001）。如果幼猴与父亲的关系相关行为表现更为突出，那么雌性个体的叫声就会减少（p=0.01），即使女儿与父亲分开，这种应激缓冲效应仍然存在（p=0.001）。虽然这些处理并没有改变行为，但 OTA 处理导致了血浆皮质醇水平的最大升高（p<0.001），这表明 OT 受体的阻断可以抑制父亲的应激缓冲作用。值得注意的是，具有更强烈父女关系相关行为表现的雌性个体表现出整体减少的生理分离应激反应（p=0.04）。本研究的结果推进了女性纽带的神经生物学机制的现有知识，并有助于说明社交干扰如何根据与纽带相关行为的表达而对个体产生不同的影响。
