Haug M, Spetz J F, Brain P F, Mandel P
Gen Pharmacol. 1986;17(4):493-5. doi: 10.1016/0306-3623(86)90201-6.
The effect of the narcotic antagonist naloxone (a mu blocker at low doses) on the attack displayed by castrated male mice towards lactating intruders was investigated. Naloxone at doses of 1 mg and 2 mg/kg decreased attacks an effect which was also evident to a lesser extent at 0.75 mg/kg. These findings suggest a role for endogenous opiates in the expression of this form of aggression although one must warn that naloxone at some of the higher doses used here can influence kappa and delta receptors as well as gabaergic activity. The interrelationships between endogenous opioids, gabaergic neurotransmission and gonadal hormones in the regulation of this attack response are discussed.
研究了麻醉拮抗剂纳洛酮（低剂量时为μ受体阻滞剂）对去势雄性小鼠对哺乳期入侵者表现出的攻击行为的影响。剂量为1毫克/千克和2毫克/千克的纳洛酮可减少攻击行为，在0.75毫克/千克时这种效果也有一定程度的体现。这些发现表明内源性阿片类物质在这种攻击行为的表达中发挥作用，不过必须提醒的是，此处使用的一些较高剂量的纳洛酮会影响κ和δ受体以及γ-氨基丁酸能活性。本文还讨论了内源性阿片类物质、γ-氨基丁酸能神经传递和性腺激素在调节这种攻击反应中的相互关系。
