Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha 410011, PR China.
Changsha Stomatological Hospital, Changsha 410005, PR China.
Int J Biol Macromol. 2023 Nov 1;251:126333. doi: 10.1016/j.ijbiomac.2023.126333. Epub 2023 Aug 14.
Oral ulcers are common in the oral mucosa. Frequent occurrences of oral ulcers commonly afflict patients, seriously impacting their daily life. Treatments with good anti-inflammatory and antibacterial properties are important for promoting the healing of oral ulcers. In this study, a multifunctional, soluble hyaluronic acid (HA) microneedle (MN) patch was prepared to promote oral ulcer healing. The tip layer of the MN patch was loaded with triamcinolone acetonide (TA) and epidermal growth factor (EGF) to inhibit inflammation and promote angiogenesis. Zeolitic imidazolate framework-8 (ZIF-8) was loaded onto the base layer of the MN patch, which effectively released Zn to mediate antibacterial effects. In addition, HA exerts a protective effect on the mucous membrane. Owing to these properties, the multifunctional MN patches were found to have good anti-inflammatory, antibacterial, and tissue-healing abilities, indicating that the multifunctional MN patch design successfully promoted the healing of oral ulcers.
口腔黏膜溃疡较为常见。口腔溃疡常反复发作，严重影响患者的日常生活。具有良好抗炎和抗菌性能的治疗方法对于促进口腔溃疡的愈合非常重要。在这项研究中，制备了一种多功能、可溶的透明质酸（HA）微针（MN）贴片，以促进口腔溃疡愈合。MN 贴片的针尖层装载曲安奈德（TA）和表皮生长因子（EGF），以抑制炎症和促进血管生成。沸石咪唑骨架-8（ZIF-8）装载到 MN 贴片的基底层上，可有效释放 Zn 来介导抗菌作用。此外，HA 对粘膜具有保护作用。由于这些特性，发现多功能 MN 贴片具有良好的抗炎、抗菌和组织愈合能力，表明多功能 MN 贴片设计成功促进了口腔溃疡的愈合。
