Kotani Yuki, Pruna Alessandro, Landoni Giovanni
Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
J Cardiothorac Vasc Anesth. 2023 Nov;37(11):2176-2180. doi: 10.1053/j.jvca.2023.07.032. Epub 2023 Jul 29.
Due to its favorable pharmacologic features, propofol is the most commonly used hypnotic agent in perioperative and intensive care settings. However, it also has adverse effects like propofol infusion syndrome and an increased risk of infection. Growing evidence suggests that propofol may worsen clinical outcomes by inhibiting the organ-protective properties of other interventions, such as volatile anesthetics or remote ischemic preconditioning. This editorial describes possible mechanisms underlying the detrimental effects of propofol, and provides an overview of the results of clinical trials evaluating the effects of propofol in various settings.
由于其良好的药理学特性，丙泊酚是围手术期和重症监护环境中最常用的催眠药物。然而，它也有诸如丙泊酚输注综合征和感染风险增加等不良反应。越来越多的证据表明，丙泊酚可能会通过抑制其他干预措施（如挥发性麻醉剂或远程缺血预处理）的器官保护特性而使临床结果恶化。这篇社论描述了丙泊酚有害作用的潜在机制，并概述了评估丙泊酚在各种环境中作用的临床试验结果。
