Orthopedic Department II, Cangzhou Hospital of Integrated TCM-WM, Hebei, China.
Pak J Pharm Sci. 2023 May;36(3(Special)):921-925.
To investigate the effects of glucosamine hydrochloride combined with non-steroidal anti-inflammatory drugs on symptoms and HSS scores in patients with knee osteoarthritis (KOA). Totally 80 cases of patients with KOA admitted to Cangzhou Hospital of integrated TCM-WM from February 2016 to December 2019 were selected and divided into the Control Group and Observation Group by Random Number Table Method, with 40 cases in each group. After treatment, the Observation Group tends to have lower VAS scores and WOMAC scores than the Control Group (P<0.05). The Observation Group tends to perform better than the Control Group on symptom improvement rate and HSS scores (P<0.05). The expression levels of related inflammatory factors and matrix metalloproteinase (MMPs) are similar before and after treatment in the Control Group (P>0.05). The expression levels of related inflammatory factors and MMPs get lower after treatment in the Observation Group (P<0.05). The evaluation indexes and total scores of the Observation Group are better than those of the Control Group (P<0.05). Glucosamine hydrochloride combined with non-steroidal anti-inflammatory drugs treatment could decrease the expression levels of inflammatory cytokines, relieve knee pain and arthritis symptoms, improve knee function and improve the HSS scores in patients with KOA.
探讨盐酸氨基葡萄糖联合非甾体类抗炎药治疗膝骨关节炎（KOA）患者的临床效果。
选取 2016 年 2 月至 2019 年 12 月沧州市中西医结合医院收治的 80 例 KOA 患者，采用随机数字表法分为对照组和观察组，每组 40 例。
治疗后，观察组的 VAS 评分和 WOMAC 评分均低于对照组（P<0.05）；观察组的症状改善率和 HSS 评分均优于对照组（P<0.05）；治疗前后对照组患者相关炎性因子和基质金属蛋白酶（MMPs）的表达水平比较差异无统计学意义（P>0.05）；观察组患者相关炎性因子和 MMPs 的表达水平均低于治疗前（P<0.05）；观察组的评估指标和总分均优于对照组（P<0.05）。
盐酸氨基葡萄糖联合非甾体类抗炎药治疗可降低 KOA 患者炎性细胞因子的表达水平，缓解膝关节疼痛和关节炎症状，改善膝关节功能，提高 HSS 评分。
