Hanzl Lukáš, Vinklárek Jaromír, Honzíček Jan, Dostál Libor, Císařová Ivana, Šacherlová Lucie, Eisner Aleš, Muthná Darina, Řezáčová Martina
Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.
Institute Chemistry and Technology of Macromolecular Materials, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.
Chempluschem. 2023 Sep;88(9):e202300374. doi: 10.1002/cplu.202300374.
A series of molybdenum(II) compounds [(η -Cp')Mo(CO) (L )][BF ] (Cp'=C H (CH ) SPh, C H (CH ) OMe, L N,N-chelating ligand) have been synthesized and characterized by spectroscopic and analytical methods including X-ray crystallography. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution in the π-ligand in combination with suitable N,N-chelating ligand can lead to species with cytotoxicity considerably higher than reported to cisplatin. Unusually high activity was observed for compounds bearing phenanthroline ligands [{η -C H (CH ) OMe}Mo(CO) (3,4,7,8-Me phen)][BF ] (IC =0.7±0.3 μM) and [{η -C H (CH ) OMe}Mo(CO) (4,7-Ph phen)][BF ] (IC values 0.8±0.4 μM).
一系列钼（II）化合物[(η -Cp')Mo(CO) (L )][BF ]（Cp'=C H (CH ) SPh、C H (CH ) OMe，L为N,N-螯合配体）已通过包括X射线晶体学在内的光谱和分析方法合成并表征。对人白血病细胞MOLT-4的体外试验表明，π-配体中的取代与合适的N,N-螯合配体相结合可产生细胞毒性远高于顺铂报道值的物种。对于带有菲咯啉配体的化合物[{η -C H (CH ) OMe}Mo(CO) (3,4,7,8-Me phen)][BF ]（IC =0.7±0.3 μM）和[{η -C H (CH ) OMe}Mo(CO) (4,7-Ph phen)][BF ]（IC值为0.8±0.4 μM）观察到异常高的活性。
