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Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia.

作者信息

Liu Yumei, Niu Haiyue, Ren Jie, Wang Zhiqin, Yan Li, Xing Limin, Shao Zonghong, Fu Rong, Cai Zhigang, Wang Huaquan

机构信息

Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China.

School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.

出版信息

Genes Dis. 2023 Apr 5;11(1):49-52. doi: 10.1016/j.gendis.2023.03.002. eCollection 2024 Jan.

DOI:10.1016/j.gendis.2023.03.002
PMID:37588205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10425790/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10425790/4ce179bf444e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10425790/4ce179bf444e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab3/10425790/4ce179bf444e/gr1.jpg

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Cell Discov. 2022 May 10;8(1):41. doi: 10.1038/s41421-022-00389-z.
2
Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia.单细胞分析人类骨髓祖细胞揭示 Diamond-Blackfan 贫血中红细胞生成失败的机制。
Sci Transl Med. 2021 Sep 8;13(610):eabf0113. doi: 10.1126/scitranslmed.abf0113.
3
Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1.
Ann Hematol. 2025 Feb;104(2):953-961. doi: 10.1007/s00277-025-06220-5.
4
STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis.STK10 突变通过损害核糖体生物发生来阻断获得性纯红细胞再生障碍性贫血中的红细胞生成。
Ann Hematol. 2024 Aug;103(8):2711-2720. doi: 10.1007/s00277-024-05802-z. Epub 2024 May 18.
热休克蛋白 70/GATA1 对 Diamond-Blackfan 贫血珠蛋白-血红素平衡的调控。
Blood. 2019 Mar 21;133(12):1358-1370. doi: 10.1182/blood-2018-09-875674. Epub 2019 Jan 30.
4
Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry.单细胞 RNA 测序、液质联用技术和流式细胞术评估人类骨髓。
JCI Insight. 2018 Dec 6;3(23):124928. doi: 10.1172/jci.insight.124928.
5
Pure red cell aplasia.纯红细胞再生障碍。
Blood. 2016 Nov 24;128(21):2504-2509. doi: 10.1182/blood-2016-05-717140.