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维生素D在哮喘管理中的治疗潜力:文献综述

Therapeutic Potential of Vitamin D in Management of Asthma: A Literature Review.

作者信息

Tibrewal Charu, Modi Naisargi Shrikant, Bajoria Parth S, Dave Prathma Anandbhai, Rohit Ralph Kingsford, Patel Priyansh, Gandhi Siddharth Kamal, Gutlapalli Sai Dheeraj, Gottlieb Peter, Nfonoyim Jay

机构信息

Department of Internal Medicine, Civil Hospital Ahmedabad, Ahmedabad, IND.

Department of Internal Medicine, GMERS Medical College Gandhinagar, Gandhinagar, IND.

出版信息

Cureus. 2023 Jul 16;15(7):e41956. doi: 10.7759/cureus.41956. eCollection 2023 Jul.

Abstract

Asthma, a prevalent chronic respiratory illness, affects a substantial number of individuals worldwide, with an estimated occurrence of 358 million cases. Evidence for the benefits of vitamin D in treating asthma is ambiguous and contradictory. The goal of this review article is to emphasize the value of vitamin D supplementation for people with asthma. Medical subject headings (MeSH) terminology was used to search the PubMed Central, MEDLINE, and PubMed databases for articles on vitamin D supplementation in asthma patients. We selected a comprehensive range of academic writing examples published in English, encompassing various types of texts. The study included a total of 37 papers, of which 18 were randomized controlled trials (RCTs) and five were meta-analyses. The use of a corticosteroid, with or without the inclusion of an adrenergic receptor agonist, improves the disease's symptoms, but it is unable to halt the long-term decline in lung function. Over the past 20 years, vitamin D has developed into a potent immunomodulator, influencing both immunological and structural cells, most notably airway smooth muscle cells. Among adults with low 25-hydroxyvitamin D levels, the administration of vitamin D supplements was found to have positive effects in a reduction in the likelihood of asthma exacerbations requiring systemic corticosteroids. The provision of vitamin D supplements during pregnancy significantly reduces the risk of asthma in babies. Both children and adults with inadequate vitamin D levels who have been given vitamin D supplements have shown evident preventive effects against asthma. Therefore, we conclude there should be a lower threshold for prescribing vitamin D to patients with asthma who are vitamin D deficient.

摘要

哮喘是一种常见的慢性呼吸道疾病,全球有大量人群受其影响,估计病例数达3.58亿。维生素D治疗哮喘的益处证据尚不明确且相互矛盾。这篇综述文章的目的是强调补充维生素D对哮喘患者的价值。使用医学主题词(MeSH)术语在PubMed Central、MEDLINE和PubMed数据库中搜索关于哮喘患者补充维生素D的文章。我们选择了一系列以英文发表的全面学术写作范例,涵盖各种类型的文本。该研究共纳入37篇论文,其中18篇为随机对照试验(RCT),5篇为荟萃分析。使用皮质类固醇,无论是否加入肾上腺素能受体激动剂,都能改善疾病症状,但无法阻止肺功能的长期下降。在过去20年中,维生素D已发展成为一种强大的免疫调节剂,影响免疫细胞和结构细胞,尤其是气道平滑肌细胞。在25-羟基维生素D水平较低的成年人中,补充维生素D被发现对降低需要全身使用皮质类固醇的哮喘加重可能性有积极作用。孕期补充维生素D可显著降低婴儿患哮喘的风险。维生素D水平不足的儿童和成年人补充维生素D后,对哮喘均显示出明显的预防作用。因此,我们得出结论,对于维生素D缺乏的哮喘患者,应降低维生素D处方的阈值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b6c/10425698/0806d0ebe26b/cureus-0015-00000041956-i01.jpg

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