Luo Liang, Chen Guanglei, Zhou Yan, Xiang YaJun, Peng Jing
School of TCM Health Care, Leshan Vocational of Technical College, Leshan, Sicuan Province, China.
School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China.
Front Nutr. 2024 May 23;11:1401881. doi: 10.3389/fnut.2024.1401881. eCollection 2024.
Currently, there is limited and inconsistent evidence regarding the risk association between daily dietary intake, antioxidants, minerals, and vitamins with Childhood Asthma (CA). Therefore, this study employs Mendelian Randomization (MR) methodology to systematically investigate the causal relationships between daily dietary intake, serum antioxidants, serum minerals, and the circulating levels of serum vitamins with
This study selected factors related to daily dietary intake, including carbohydrates, proteins, fats, and sugars, as well as serum antioxidant levels (lycopene, uric acid, and β-carotene), minerals (calcium, copper, selenium, zinc, iron, phosphorus, and magnesium), and vitamins (vitamin A, vitamin B6, folate, vitamin B12, vitamin C, vitamin D, and vitamin E), using them as Instrumental Variables (IVs). Genetic data related to CA were obtained from the FinnGen and GWAS Catalog databases, with the primary analytical methods being Inverse Variance Weighting (IVW) and sensitivity analysis.
Following MR analysis, it is observed that sugar intake (OR: 0.71, 95% CI: 0.55-0.91, P: 0.01) is inversely correlated with the risk of CA, while the intake of serum circulating magnesium levels (OR: 1.63, 95% CI: 1.06-2.53, P: 0.03), fats (OR: 1.44, 95% CI: 1.06-1.95, P: 0.02), and serum vitamin D levels (OR: 1.14, 95% CI: 1.04-1.25, P: 0.02) are positively associated with an increased risk of
This study identified a causal relationship between the daily dietary intake of sugars and fats, as well as the magnesium and vitamin D levels in serum, and the occurrence of However, further in-depth research is warranted to elucidate the specific mechanisms underlying these associations.
目前，关于日常饮食摄入、抗氧化剂、矿物质和维生素与儿童哮喘（CA）之间的风险关联，证据有限且不一致。因此，本研究采用孟德尔随机化（MR）方法，系统地研究日常饮食摄入、血清抗氧化剂、血清矿物质和血清维生素循环水平之间的因果关系。
本研究选择了与日常饮食摄入相关的因素，包括碳水化合物、蛋白质、脂肪和糖，以及血清抗氧化剂水平（番茄红素、尿酸和β-胡萝卜素）、矿物质（钙、铜、硒、锌、铁、磷和镁）和维生素（维生素A、维生素B6、叶酸、维生素B12、维生素C、维生素D和维生素E），将它们用作工具变量（IVs）。与CA相关的遗传数据来自芬兰基因库（FinnGen）和全基因组关联研究目录（GWAS Catalog）数据库，主要分析方法为逆方差加权（IVW）和敏感性分析。
经过MR分析，发现糖摄入量（OR：0.71，95%CI：0.55 - 0.91，P：0.01）与CA风险呈负相关，而血清循环镁水平摄入量（OR：1.63，95%CI：1.06 - 2.53，P：0.03）、脂肪摄入量（OR：1.44，95%CI：1.06 - 1.95，P：0.02）和血清维生素D水平（OR：1.14，95%CI：1.04 - 1.25，P：0.02）与CA风险增加呈正相关。
本研究确定了日常饮食中糖和脂肪的摄入量以及血清中镁和维生素D水平与CA发生之间的因果关系。然而，有必要进行进一步深入研究以阐明这些关联背后的具体机制。
