Merkel Carlin A, Brady Kenneth M, Votava-Smith Jodie K, Tran Nhu N
Keck School of Medicine, Los Angeles, CA, USA.
Division of Cardiac Anesthesia, Northwestern University Feinberg School of Medicine and Ann & Robert H, Lurie Children's Hospital of Chicago, Chicago, IL, USA.
J Clin Transl Sci. 2023 Jul 10;7(1):e165. doi: 10.1017/cts.2023.581. eCollection 2023.
Infants with congenital heart disease (CHD) may have impaired cerebral autoregulation (CA) associated with cerebral fractional tissue oxygen extraction (FTOE). We conducted a pilot study in nine CHD neonates to validate a noninvasive CA measure, cerebrovascular stability index (CSI), by eliciting responses to postural tilts. We compared CSI to an invasive measure of CA and to FTOE collected during tilts (FTOE). FTOE correlated with CSI, as did the change in FTOE during tilts, but CSI's correlation with impaired CA did not reach significance. Larger trials are indicated to validate CSI, allowing for noninvasive CA measurements and measurements in outpatient settings.
患有先天性心脏病（CHD）的婴儿可能存在与脑部分组织氧摄取（FTOE）相关的脑自动调节（CA）受损。我们对9名CHD新生儿进行了一项初步研究，通过引发对姿势倾斜的反应来验证一种非侵入性CA测量方法——脑血管稳定性指数（CSI）。我们将CSI与CA的侵入性测量方法以及倾斜过程中收集的FTOE进行了比较。FTOE与CSI相关，倾斜过程中FTOE的变化也与CSI相关，但CSI与受损CA的相关性未达到显著水平。需要进行更大规模的试验来验证CSI，以便能够进行非侵入性CA测量以及在门诊环境中进行测量。
