炎症性肠病中的骨骼健康。

Bone health in inflammatory bowel disease.

机构信息

Thoracic Oncology Ward, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Department of Cardiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

出版信息

Expert Rev Gastroenterol Hepatol. 2023 Jul-Dec;17(9):921-935. doi: 10.1080/17474124.2023.2248874. Epub 2023 Aug 20.

DOI:10.1080/17474124.2023.2248874

PMID:37589220

Abstract

INTRODUCTION

Inflammatory bowel disease (IBD) is a chronic disease characterized by the presence of systemic inflammation, manifesting not only as gastrointestinal symptoms but also as extraintestinal bone complications, including osteopenia and osteoporosis. However, the association between IBD and osteoporosis is complex, and the presence of multifactorial participants in the development of osteoporosis is increasingly recognized. Unlike in adults, delayed puberty and growth hormone/insulin-like growth factor-1 axis abnormalities are essential risk factors for osteoporosis in pediatric patients with IBD.

AREAS COVERED

This article reviews the potential pathophysiological mechanisms contributing to osteoporosis in adult and pediatric patients with IBD and provides evidence for effective prevention and treatment, focusing on pediatric patients with IBD. A search was performed from PubMed and Web of Science inception to February 2023 to identify articles on IBD, osteoporosis, pediatric, and fracture risk.

EXPERT OPINION

A comprehensive treatment pattern based on individualized principles can be used to manage pediatric IBD-related osteoporosis.

摘要

简介

炎症性肠病（IBD）是一种慢性疾病，其特征为全身炎症的存在，不仅表现为胃肠道症状，还表现为肠道外骨骼并发症，包括骨质疏松和骨量减少。然而，IBD 和骨质疏松之间的关联很复杂，越来越多的人认识到多种因素参与了骨质疏松的发生。与成人不同，青春期延迟和生长激素/胰岛素样生长因子-1 轴异常是导致 IBD 儿科患者骨质疏松的重要危险因素。