Underwood L E, Clemmons D R, Maes M, D'Ercole A J, Ketelslegers J M
Horm Res. 1986;24(2-3):166-76. doi: 10.1159/000180556.
Nutritional intake is an important regulator of plasma somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) concentrations in plasma. Concentrations in humans are reduced to the hypopituitary range by fasting for only a few days, and their normalization after fasting depends on the adequacy of energy and protein in the refeeding diet. The changes correlate with changes in nitrogen balance. In rats we have observed a close relationship between change in plasma Sm-C/IGF-I and hepatic GH binding with fasting and refeeding, suggesting that alterations in GH binding might be responsible partly for changes in Sm-C/IGF-I. When malnourished humans are given nutrient repletion, the increase in Sm-C/IGF-I is far more dramatic than changes in other nutrient-related serum proteins.
营养摄入是血浆中生长调节素-C/胰岛素样生长因子I（Sm-C/IGF-I）浓度的重要调节因素。仅禁食几天，人体血浆中该物质的浓度就会降至垂体功能减退的范围，禁食后其恢复正常取决于再喂养饮食中能量和蛋白质的充足程度。这些变化与氮平衡的变化相关。在大鼠中，我们观察到血浆Sm-C/IGF-I的变化与禁食和再喂养时肝脏生长激素结合之间存在密切关系，这表明生长激素结合的改变可能部分导致了Sm-C/IGF-I的变化。当给营养不良的人补充营养时，Sm-C/IGF-I的增加比其他营养相关血清蛋白的变化更为显著。
