Institute for Fish and Wildlife Health, University of Bern, 3012 Bern, Switzerland.
Dis Aquat Organ. 2023 Aug 17;155:73-78. doi: 10.3354/dao03738.
Glomerulocystic kidney (GCK) is defined by a dilatation of the Bowman's space (greater than 2 times the normal size) of more than 5% of all glomeruli. Although GCK has been occasionally documented in dogs, cats, and humans with renal failure, in fish, reports of spontaneous GCK are rare. For the present study, 2 captive adult red piranhas Pygocentrus nattereri from a closed population were submitted for post-mortem examination. Clinical history included lethargy, inappetence, dyspnea, and altered buoyancy. Macroscopically, the fish displayed coelomic distension and ascites. The kidneys were markedly enlarged and dark yellow. Histologically, Bowman's space was noticeably dilated, occasionally with atrophic glomerular tufts. Degeneration and necrosis of the tubular epithelium, infiltration, and nephrocalcinosis were also present. To the authors' knowledge, this present study is the first report of spontaneously occurring GCK in red piranhas and freshwater fish in general. Despite being rare, GCK is a condition with the potential to impair the health of fish and mammals, and further studies are needed to shed new light on this condition.
肾小球囊泡肾（GCK）的定义为超过 5%的肾小球的Bowman 空间扩张（大于正常大小的 2 倍）。尽管在患有肾衰竭的犬、猫和人中偶尔会记录到 GCK，但在鱼类中，自发性 GCK 的报道很少。在本研究中，2 只来自封闭种群的成年红腹食人鲳 Pygocentrus nattereri 因死后检查而被提交。临床病史包括嗜睡、食欲不振、呼吸困难和浮力改变。大体上，鱼显示体腔膨胀和腹水。肾脏明显肿大，呈暗黄色。组织学上，Bowman 空间明显扩张，偶尔伴有萎缩性肾小球簇。肾小管上皮细胞变性和坏死、浸润和肾钙质沉着也存在。据作者所知，本研究首次报道了红腹食人鲳和一般淡水鱼中自发性 GCK 的发生。尽管罕见，但 GCK 是一种可能损害鱼类和哺乳动物健康的疾病，需要进一步的研究来阐明这种疾病。
