在布基纳法索，15 个月大的儿童接种伤寒结合疫苗后，体内产生了持久的抗-Vi IgG 和 IgA 抗体应答。
Durable Anti-Vi IgG and IgA Antibody Responses in 15-Month-Old Children Vaccinated With Typhoid Conjugate Vaccine in Burkina Faso.
机构信息
Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso.
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
出版信息
J Pediatric Infect Dis Soc. 2023 Sep 27;12(9):513-518. doi: 10.1093/jpids/piad058.
We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30-35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15 months.
我们评估了在布基纳法索开展的一项双盲随机对照 2 期临床试验中入组儿童的伤寒 Vi 多糖结合疫苗（TCV）的抗-Vi IgG/IgA 应答。在接种后 30-35 个月，TCV 组的抗-Vi IgG 血清转化率和抗-Vi IgA 滴度均高于对照组。在 15 个月龄时接种 TCV 的布基纳法索儿童可产生持久的免疫。
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