Huong Nguyen Thi, Hop Nguyen Quang, Son Ninh The
Faculty of Chemical Technology, Hanoi University of Industry, Hanoi, Vietnam.
Faculty of Chemistry, Hanoi Pedagogical University 2 (HPU2), Vinhphuc, Vietnam.
J Pharm Pharmacol. 2023 Oct 5;75(10):1259-1293. doi: 10.1093/jpp/rgad074.
The genus Cratoxylum contained medicinal herbs, which are widely distributed in South-East Asia and China. Plants of this genus were consumed as a vegetable side dish, a spice, an ingredient in soup, or a substitute for tea, as well as they are traditionally appropriate for various diseases such as fever, cough, flu, diarrhoea, etc. The most aims of the current review are to highlight the ultimate information about the traditional use, phytochemistry and pharmacology of Cratoxylum medicinal plants.
The relevant literature data of Cratoxylum species have been gathered from Google Scholar, Sci-Finder, Web of Science, Science Direct and various journal websites. The most meaningful keyword 'Cratoxylum' was used in combination or alone in the search for references.
More than 150 reports have been retrieved from the search, completely written in English. Most of them are phytochemical and pharmacological studies, which determined the isolations of 277 metabolites. Xanthone derivatives (205 compounds, 74%) are essential, followed by other chemical classes such as flavonoids, anthraquinones, triterpenoids, benzophenones, phytosterols and tocopherols. Cratoxylum constituents possessed complexed pharmacological activities, including antioxidant, antibacterial, anti-inflammatory, antidiabetic, antihypertensive, antimalarial, antiviral, antiamoebic, protein tyrosine phosphatase 1B inhibitory, neuroprotective, hepatoprotective and gastroprotective activities, especially in terms of anticancer.
黄牛木属包含多种药用植物，广泛分布于东南亚和中国。该属植物可作为蔬菜配菜、香料、汤品原料或茶的替代品食用，并且传统上适用于多种疾病，如发烧、咳嗽、流感、腹泻等。本次综述的主要目的是着重介绍黄牛木属药用植物在传统用途、植物化学和药理学方面的最终信息。
已从谷歌学术、Sci-Finder、科学网、科学Direct以及各种期刊网站收集了黄牛木属物种的相关文献数据。在搜索参考文献时，最具意义的关键词“黄牛木属”单独使用或与其他词组合使用。
搜索共检索到150多篇完全用英文撰写的报告。其中大部分是植物化学和药理学研究，确定了277种代谢物的分离情况。氧杂蒽酮衍生物（205种化合物，占74%）是主要成分，其次是其他化学类别，如黄酮类、蒽醌类、三萜类、二苯甲酮类、植物甾醇类和生育酚类。黄牛木属成分具有多种药理活性，包括抗氧化、抗菌、抗炎、抗糖尿病、抗高血压、抗疟疾、抗病毒、抗阿米巴、蛋白酪氨酸磷酸酶1B抑制、神经保护、肝脏保护和胃保护活性，尤其是在抗癌方面。
