Continuum (Minneap Minn). 2023 Aug 1;29(4):1205-1233. doi: 10.1212/CON.0000000000001285.
This article provides a comprehensive review of pediatric sleep disorders including the clinical features, diagnosis, and treatment of sleep-disordered breathing, insomnia, parasomnias, restless sleep disorder, restless legs syndrome, narcolepsy in childhood, and Kleine-Levin syndrome.
Our understanding of pediatric sleep pathophysiology continues to evolve, and diagnostic and treatment modalities have expanded. A low-sodium oxybate formulation was approved in July 2020 in the United States to treat cataplexy and excessive daytime sleepiness in patients 7 years old and older with narcolepsy. A validated pediatric hypersomnolence survey for pediatric narcolepsy and idiopathic hypersomnia with high sensitivity, specificity, and interrater reliability is now available.
The clinical presentation, diagnostics, and treatment of children with sleep disorders differ from those of adults. Untreated sleep disorders in childhood can lead to adverse physical and psychological consequences in adults. Correctly diagnosing and treating sleep disorders in youth can prevent a significant burden of disease in adulthood.
本文全面综述了儿科睡眠障碍,包括睡眠呼吸障碍、失眠、睡眠行为障碍、不宁腿综合征、周期性肢体运动障碍、儿童发作性睡病和 Kleine-Levin 综合征的临床特征、诊断和治疗。
我们对儿科睡眠病理生理学的理解在不断发展,诊断和治疗方法也在不断扩展。2020 年 7 月,在美国低钠羟丁酸钠制剂获批用于治疗 7 岁及以上发作性睡病患者的猝倒和日间过度嗜睡。目前已有一种经验证的儿科发作性睡病和特发性嗜睡障碍的儿童嗜睡症调查,具有较高的敏感性、特异性和组内信度。
儿童睡眠障碍的临床表现、诊断和治疗与成人不同。儿童时期未经治疗的睡眠障碍可导致成年后患各种身心疾病。正确诊断和治疗青少年的睡眠障碍可以预防成年后患严重疾病。