MCC950 通过减轻 SAH 后大鼠的白质微观结构损伤改善认知功能。
MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH.
机构信息
Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
出版信息
Brain Res Bull. 2023 Oct 1;202:110743. doi: 10.1016/j.brainresbull.2023.110743. Epub 2023 Aug 15.
Neuroinflammation and white matter microstructure damage are important causes of cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 (NLRP3) plays an important role in neuroinflammation after SAH and may be a potential therapeutic target for treatment of white matter microstructure injury. In this study, we observed whether MCC950, a specific inhibitor of the NLRP3 inflammasome, exerted a therapeutic effect after SAH. The SAH model was induced by endovascular perforation in SpragueDawley rats. MCC950 was injected intraperitoneally 1 h after SAH at a dose of 10 mg/kg. The results showed that MCC950 significantly attenuated white matter microstructure damage in some brain regions, and behavioral experiments confirmed that MCC950 ameliorated cognitive function in rats after SAH, which may provide a new method for the treatment of cognitive dysfunction in SAH patients.
神经炎症和白质微观结构损伤是蛛网膜下腔出血（SAH）后认知障碍的重要原因。核苷酸结合寡聚化结构域样受体蛋白 3（NLRP3）在 SAH 后神经炎症中发挥重要作用，可能是治疗白质微观结构损伤的潜在治疗靶点。在这项研究中，我们观察了 NLRP3 炎性体的特异性抑制剂 MCC950 在 SAH 后是否具有治疗作用。通过 SpragueDawley 大鼠血管内穿孔诱导 SAH 模型。SAH 后 1 小时，以 10mg/kg 的剂量腹腔内注射 MCC950。结果表明，MCC950 可显著减轻部分脑区白质微观结构损伤，行为学实验证实 MCC950 可改善 SAH 大鼠的认知功能，为治疗 SAH 患者认知功能障碍提供了新方法。
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