Seow W K, Li S Y, Thong Y H
Immunol Lett. 1986 Aug;13(1-2):83-8. doi: 10.1016/0165-2478(86)90131-8.
Tetrandrine is a plant alkaloid useful in the treatment of silicosis. Its mode of action is unknown, but results of the present study show dose-dependent inhibition of human neutrophil and monocyte adherence at concentrations (0.1-10 micrograms/ml) easily achieved in plasma during drug therapy. Monocytes were shown to be more sensitive to tetrandrine than neutrophils. Dye-exclusion experiments indicate that tetrandrine is non-toxic to these cells at 10 micrograms/ml concentrations. Suppression of adherence was reversible by washing, suggesting that the drug does not bind tightly to membrane components. Enhancement of adherence by the tumour promoter, phorbol myristate acetate, was abolished by tetrandrine. The uptake of deoxyglucose by neutrophils and monocytes was suppressed by tetrandrine. These results indicate that tetrandrine may act by interfering with the recruitment of these cells into silicotic lesions.
粉防己碱是一种可用于治疗矽肺的植物生物碱。其作用机制尚不清楚，但本研究结果表明，在药物治疗期间血浆中容易达到的浓度（0.1 - 10微克/毫升）下，它对人中性粒细胞和单核细胞的黏附具有剂量依赖性抑制作用。单核细胞对粉防己碱比中性粒细胞更敏感。染料排除实验表明，在10微克/毫升浓度下粉防己碱对这些细胞无毒。通过洗涤可使黏附抑制作用逆转，这表明该药物不会与膜成分紧密结合。粉防己碱消除了肿瘤促进剂佛波酯肉豆蔻酸酯乙酸盐对黏附的增强作用。粉防己碱抑制中性粒细胞和单核细胞对脱氧葡萄糖的摄取。这些结果表明，粉防己碱可能通过干扰这些细胞向矽肺病变部位的募集而发挥作用。
