Visiting Clinical Research Associate, Huddersfield University, Huddersfield, UK.
Medical Marketing Consultant, Daneriver Consultancy Ltd., Holmes Chapel, UK.
J Wound Care. 2023 Aug 1;32(Sup8a):S13-S22. doi: 10.12968/jowc.2023.32.Sup8a.S13.
To update the evidence in relation to the use of dialkylcarbamoyl chloride (DACC)-coated wound dressings in the prevention, treatment and management of wounds.
PubMed and PubMed Central databases were searched to identify articles published since 2020 describing the experimental and clinical evidence for DACC-coated dressings, and their antimicrobial effect, as well as their impact on the prevention and treatment of infected wounds. The identified articles were then narratively reviewed.
The search yielded 113 articles (plus references from ad hoc sources), of which nine met the inclusion criteria. Of the nine included studies, five related to clinical aspects and four were laboratory studies.
A number of new studies have provided further evidence for the mode of action of the antimicrobial effect of DACC-coated dressings and its wide spectrum effect (including World Health Organization-prioritised microorganisms). Additional clinical studies have provided evidence of new applications, such as in treating wounds in paediatric patients, and extended the evidence relating to their use in treating surgical site infections. Evidence also shows that DACC-coated wound dressings can aid in the binding of biofilms, and how this technology can align and support antimicrobial stewardship in the prevention of antimicrobial resistance.
更新与使用二烷基碳酰氯（DACC）涂层伤口敷料预防、治疗和管理伤口相关的证据。
检索 PubMed 和 PubMed Central 数据库，以确定自 2020 年以来描述 DACC 涂层敷料的实验和临床证据、其抗菌效果，以及其对感染性伤口预防和治疗的影响的文章。然后对所确定的文章进行叙述性综述。
搜索结果产生了 113 篇文章（外加来自特定来源的参考文献），其中 9 篇符合纳入标准。在这 9 项纳入的研究中，有 5 项与临床方面有关，有 4 项是实验室研究。
一些新的研究为 DACC 涂层敷料的抗菌作用及其广谱效应（包括世界卫生组织优先微生物）的作用机制提供了进一步的证据。此外的临床研究提供了新应用的证据，例如治疗儿科患者的伤口，并扩展了其在治疗手术部位感染方面的应用证据。证据还表明，DACC 涂层伤口敷料有助于结合生物膜，以及这项技术如何在预防抗菌药物耐药性方面与抗菌药物管理保持一致并提供支持。
