单克隆抗体：诊断神经放射学家需要了解的知识。
Monoclonal Antibodies: What the Diagnostic Neuroradiologist Needs to Know.
机构信息
From the Division of Neuroradiology, Department of Medical Imaging (R.A., T.K.), University of Toronto, Toronto Western Hospital, University Health Network and University Medical Imaging, Toronto, Ontario, Canada.
Department of Diagnostic Imaging (R.A.), Peterborough Regional Health Centre, Peterborough, Ontario, Canada.
出版信息
AJNR Am J Neuroradiol. 2023 Dec 11;44(12):1358-1366. doi: 10.3174/ajnr.A7974.
Monoclonal antibodies have become increasingly popular as novel therapeutics against a variety of diseases due to their specificity, affinity, and serum stability. Due to the nearly infinite repertoire of monoclonal antibodies, their therapeutic use is rapidly expanding, revolutionizing disease course and management, and what is now considered experimental therapy may soon become approved practice. Therefore, it is important for radiologists, neuroradiologists, and neurologists to be aware of these drugs and their possible different imaging-related manifestations, including expected and adverse effects of these novel drugs. Herein, we review the most commonly used monoclonal antibody-targeted therapeutic agents, their mechanism of action, clinical applications, and major adverse events with a focus on neurologic and neurographic effects and discuss differential considerations, to assist in the diagnosis of these conditions.
由于单克隆抗体具有特异性、亲和力和血清稳定性，因此已成为针对各种疾病的新型治疗药物而越来越受欢迎。由于单克隆抗体的 repertoire 几乎是无限的，因此它们的治疗用途正在迅速扩展，彻底改变了疾病的进程和管理方式，而现在被认为是实验性治疗的方法可能很快就会成为批准的常规治疗方法。因此，放射科医生、神经放射科医生和神经科医生了解这些药物及其可能的不同与成像相关的表现非常重要，包括这些新型药物的预期和不良反应。在此，我们回顾了最常用的单克隆抗体靶向治疗药物，其作用机制、临床应用以及主要的不良事件，重点讨论了神经和神经影像学方面的影响，并讨论了鉴别诊断的注意事项，以协助诊断这些疾病。
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