与儿童城市化相关的环境因素对大脑结构和认知的影响。
The effects of environmental factors associated with childhood urbanicity on brain structure and cognition.
机构信息
Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, 51 Huayuanbei Road, Haidian District, Beijing, 100191, China.
NHC Key Laboratory of Mental Health (Peking University), 51 Huayuanbei Road, Haidian District, Beijing, 100191, China.
出版信息
BMC Psychiatry. 2023 Aug 17;23(1):598. doi: 10.1186/s12888-023-05066-3.
Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety male and female adult Chinese Han participants with different urban and rural childhoods were included in this study. Early-life urban environment was found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed that maternal education was a protective factor for total and DLPFC GMVs, while having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. These findings may suggest some pros and cons on brain structure associated with childhood urbanicity and related environmental factors.
城市化是一个持续了一个多世纪的全球趋势。本研究纳入了 499 名来自不同城乡的成年汉族男性和女性参与者。研究发现，早期城市环境有利于总灰质体积（GMV）、背外侧前额叶皮层（DLPFC）GMV、颞极（TP）GMV 和认知功能，与内侧前额叶皮层（MPFC）GMV 呈负相关。回归分析表明，母亲的教育程度是总 GMV 和 DLPFC GMV 的保护因素，而有兄弟姐妹则更有利于 MPFC GMV。总 GMV、DLPFC 和 TP GMV 在童年城市化与不同认知领域之间存在中介作用。这些发现可能表明与童年城市化和相关环境因素相关的脑结构存在一些利弊。
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