土耳其、中东、亚洲和非洲的继发性头痛障碍：一项横断面、多中心研究。

Secondary headache disorders in Turkey, the Middle East, Asia, and Africa: A cross-sectional, multicenter study.

机构信息

Department of Neurology, Cukurova University Faculty of Medicine, Adana, Turkey.

Department of Neurology, University of Health Sciences, Van Training and Research Hospital, Van, Turkey.

出版信息

Cephalalgia. 2023 Aug;43(8):3331024231194024. doi: 10.1177/03331024231194024.

DOI:10.1177/03331024231194024

PMID:37592903

Abstract

BACKGROUND

This multicenter cross-sectional study aimed to determine the frequency and characteristics of secondary headaches in different geographic regions, including Turkey, the Middle East, Asia, and Africa.

METHODS

Patients were admitted to the study on a particular day each week for five consecutive weeks between 1 April and 16 May 2022. Before the study, all researchers underwent a constructed briefing about the use and code of the ICHD-3 criteria. The study was conducted in two stages. In the first stage, data on secondary headaches were compared between the regions. In the second stage, the sub-diagnoses of secondary headaches were analyzed only in Turkey.

RESULTS

A total of 4144 (30.0%) of the 13,794 patients reported headaches as the main symptoms at admission. A total of 422 patients were excluded from the study. In total, 1249 (33.4%) of 3722 patients were diagnosed as having secondary headaches (Turkey [n = 1039], Middle East [n = 80], Asia [n = 51], Africa [n = 79]). The frequency of secondary headaches (Turkey 33.6%, Africa 30.1%, Middle East 35.5%, Asia 35.4%) did not differ significantly between the regions (p > 0.05). The most common subtype of secondary headaches was headache attributed to substances or their withdrawal in all the studied regions. There was a female predominance in all regions, but it was lower in Africa than in Turkey. The severity and density of headaches differed significantly between the regions, with patients from Africa reporting milder pain than patients from other regions. In Turkey, the most common sub-diagnoses of secondary headaches were medication overuse headache, idiopathic intracranial hypertension, and cervicogenic headache.

CONCLUSION

In the present study, one in three patients with a headache had a secondary headache. Headache attributed to substances or their withdrawal was the most common subtype of secondary headaches in all the studied regions. The female predominance of secondary headaches was lower in Africa than in Turkey. The severity and density of headaches differed significantly between regions, with patients from Africa reporting milder pain.

摘要

背景

本多中心横断面研究旨在确定不同地理区域（包括土耳其、中东、亚洲和非洲）继发性头痛的频率和特征。

方法

在 2022 年 4 月 1 日至 5 月 16 日的连续五周内，每周的特定一天将患者纳入研究。在研究之前，所有研究人员都接受了关于 ICHD-3 标准使用和编码的构建简报。该研究分两个阶段进行。在第一阶段，比较了不同地区的继发性头痛数据。在第二阶段，仅在土耳其分析了继发性头痛的亚诊断。

结果

共有 4144 名（30.0%）13794 名患者报告头痛是入院时的主要症状。共有 422 名患者被排除在研究之外。共有 1249 名（33.4%）3722 名患者被诊断为继发性头痛（土耳其 [n=1039]、中东 [n=80]、亚洲 [n=51]、非洲 [n=79]）。继发性头痛的频率（土耳其 33.6%、非洲 30.1%、中东 35.5%、亚洲 35.4%）在各地区之间无显著差异（p>0.05）。在所有研究地区，最常见的继发性头痛亚型是归因于物质或其戒断的头痛。在所有地区，女性患病率均较高，但非洲的患病率低于土耳其。头痛的严重程度和密度在各地区之间存在显著差异，非洲患者报告的疼痛程度较轻。在土耳其，继发性头痛最常见的亚诊断是药物过度使用性头痛、特发性颅内高血压和颈源性头痛。