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雪莲果叶提取物（(Poepp.) H. Rob）通过抗纤维化、抗炎和抗氧化机制对糖尿病肾病的保护作用。

Protective effect of yacon leaves extract ( (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy.

作者信息

Widowati Wahyu, Tjokropranoto Rita, Onggowidjaja Philips, Widya Kusuma Hanna Sari, Wijayanti Cahyaning Riski, Marthania Meganita, Yati Afif, Rizal Rizal

机构信息

Faculty of Medicine, Maranatha Christian University, Jl. Surya Sumantri No. 65, Bandung 40164, West Java, Indonesia.

Biomolecular and Biomedical Research Center, Aretha Medika Utama, Jl Babakan Jeruk II No. 9, Bandung 40163, West Java, Indonesia.

出版信息

Res Pharm Sci. 2023 Mar 10;18(3):336-345. doi: 10.4103/1735-5362.371589. eCollection 2023 May-Jun.

DOI:10.4103/1735-5362.371589
PMID:37593160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10427790/
Abstract

BACKGROUND AND PURPOSE

Diabetic nephropathy (DN) is a chronic kidney failure, which may lead to fatality. Mesangial cell proliferation, renal inflammation, stress oxidative, and fibrosis are involved in DN progression. Yacon leaves ( (Poepp.) H. Rob.) contains large amounts of phenolic compounds and it has the ability to inhibit oxidative stress, inflammation, and fibrosis. Considering the potential of yacon leaves extract (YLE), it may be used for DN treatment. This research aimed to elucidate YLE's potential as anti-DN through anti-inflammatory, antioxidant, and antifibrosis mechanisms.

EXPERIMENTAL APPROACH

Mesangial cells were induced by glucose 20 mM for 5 days and treated with YLE concentrations as much as 5, 10, and 50 µg/mL. TGF-β1, TNF-α, and MDA levels were measured using the ELISA method. SMAD2, SMAD3, SMAD4, and SMAD7 gene expressions were analyzed using the qRT-PCR method.

FINDINGS/RESULTS: YLE at 5, 10, and 50 µg/mL could reduce the levels of TGF-β1, TNF-α, and MDA compared with the DN cells model. YLE could reduce gene expressions of SMAD2, SMAD3, and SMAD4 and increase SMAD7 expression.

CONCLUSION AND IMPLICATIONS

YLE potentially mitigated diabetic nephropathy through antifibrosis, anti-inflammatory, and antioxidant capacities.

摘要

背景与目的

糖尿病肾病（DN）是一种慢性肾衰竭，可能导致死亡。系膜细胞增殖、肾脏炎症、氧化应激和纤维化参与了DN的进展。雪莲果叶（(Poepp.) H. Rob.）含有大量酚类化合物，具有抑制氧化应激、炎症和纤维化的能力。考虑到雪莲果叶提取物（YLE）的潜力，它可能用于DN的治疗。本研究旨在通过抗炎、抗氧化和抗纤维化机制阐明YLE作为抗DN的潜力。

实验方法

用20 mM葡萄糖诱导系膜细胞5天，并用5、10和50 µg/mL的YLE浓度进行处理。采用ELISA法测定TGF-β1、TNF-α和MDA水平。采用qRT-PCR法分析SMAD2、SMAD3、SMAD4和SMAD7基因表达。

研究结果

与DN细胞模型相比，5、10和50 µg/mL的YLE可降低TGF-β1、TNF-α和MDA水平。YLE可降低SMAD2、SMAD3和SMAD4的基因表达，并增加SMAD7的表达。

结论与启示

YLE可能通过抗纤维化、抗炎和抗氧化能力减轻糖尿病肾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/7fad57aa220a/RPS-18-336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/a85b338c6c64/RPS-18-336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/1a5376bd4c9a/RPS-18-336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/a4c049fdfe31/RPS-18-336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/7fad57aa220a/RPS-18-336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/a85b338c6c64/RPS-18-336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/1a5376bd4c9a/RPS-18-336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/a4c049fdfe31/RPS-18-336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48b/10427790/7fad57aa220a/RPS-18-336-g004.jpg

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