Lwin Yadanar, Ma David
Department of Haematology and BM Transplant, St Vincent's Hospital Sydney, NSW, Australia.
St Vincent's Clinical School, Faculty of Medicine, the University of New South Wales.
Blood Cell Ther. 2019 Jul 7;2(3):36-38. doi: 10.31547/bct-2019-001. eCollection 2019 Aug 1.
We report, to our knowledge, the first reported case of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) developing 26 years after allogeneic stem cell transplantation for chronic myeloid leukemia (CML). The second case involved de novo Ph+ALL that developed 16 years post-autologous stem cell transplantation in sustained molecular remission. These cases illustrate and raise some key issues in the management of patients with Ph+ leukemias, including the role of hematopoietic stem cell transplantation, tyrosine kinase inhibitors,and long-term post-transplantation follow-up.
据我们所知，我们报告了首例慢性髓性白血病（CML）异基因干细胞移植26年后发生费城染色体阳性急性淋巴细胞白血病（Ph+ALL）的病例。第二例是自体干细胞移植16年后在持续分子缓解状态下发生的原发性Ph+ALL。这些病例阐明并提出了Ph+白血病患者管理中的一些关键问题，包括造血干细胞移植、酪氨酸激酶抑制剂的作用以及移植后的长期随访。
