Zhang Ye, Tatewaki Yasuko, Nakase Taizen, Liu Yingxu, Tomita Naoki, Thyreau Benjamin, Zheng Haixia, Muranaka Michiho, Takano Yumi, Nagasaka Tatsuo, Taki Yasuyuki
Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Department of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, Japan.
Front Aging Neurosci. 2023 Aug 1;15:1227325. doi: 10.3389/fnagi.2023.1227325. eCollection 2023.
Present study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD].
We retrospectively included 313 patients (Mean age = 76.40 years, 59 SCD, 101 MCI, 153 AD) in a cross-sectional analysis and 91 patients (Mean age = 75.83 years, 12 SCD, 43 MCI, 36 AD) in a longitudinal analysis. Multivariable linear regression was conducted to investigate the relationship between hs-CRP concentration and brain structural alterations, and cognitive function, respectively.
Hs-CRP was positively associated with gray matter volume in the left fusiform (β = 0.16, = 0.023) and the left parahippocampal gyrus (β = 0.16, = 0.029). analysis revealed that these associations were mainly driven by patients with MCI and AD. The interaction of diagnosis and CRP was significantly associated with annual cognitive changes (β = 0.43, = 0.008). Among these patients with AD, lower baseline CRP was correlated with greater future cognitive decline ( = -0.41, = 0.013).
Our study suggests that increased hs-CRP level may exert protective effect on brain structure alterations and future cognitive changes among patients already with cognitive impairment.
本研究旨在调查在主观认知下降（SCD）、轻度认知障碍（MCI）和阿尔茨海默病（AD）背景下的超敏C反应蛋白（hs-CRP）浓度、脑结构改变和认知功能。
我们进行了一项横断面分析，回顾性纳入313例患者（平均年龄 = 76.40岁，59例SCD，101例MCI，153例AD），并进行了一项纵向分析，纳入91例患者（平均年龄 = 75.83岁，12例SCD，43例MCI，36例AD）。分别进行多变量线性回归以研究hs-CRP浓度与脑结构改变及认知功能之间的关系。
hs-CRP与左侧梭状回（β = 0.16，P = 0.023）和左侧海马旁回（β = 0.16，P = 0.029）的灰质体积呈正相关。分析显示，这些关联主要由MCI和AD患者驱动。诊断与CRP的相互作用与年度认知变化显著相关（β = 0.43，P = 0.008）。在这些AD患者中，较低的基线CRP与未来更大的认知衰退相关（r = -0.41，P = 0.013）。
我们的研究表明，hs-CRP水平升高可能对已有认知障碍的患者的脑结构改变和未来认知变化具有保护作用。
