聚二肽。13. 胶原蛋白模型结构的合成与1H核磁共振分析。
Polydepsipeptides. 13. Synthesis and 1H-n.m.r. analysis of collagen model structures.
作者信息
Mammi S, Goodman M
出版信息
Int J Pept Protein Res. 1986 Jul;28(1):29-44.
The synthesis of three collagen model analogs is described: Ac-Ala-Gly-Pro-Ala-Gly-Pro-NHMe, Ac-Ala-Gly-Pro-Ala-Glc-Pro-NHMe, and Ac-Ala-Glc-Pro-Ala-Gly-Pro-NHMe, where Glc stands for glycolic acid. The 1H-n.m.r. properties of these compounds in dimethylsulfoxide-d6 and trifluoroethanol are described. While in DMSO-d6 the compounds are random, in TFE the glycine amide protons seem to be less solvent exposed than the other amide protons. Little difference was found in the behavior of the three compounds.
描述了三种胶原蛋白模型类似物的合成
Ac-Ala-Gly-Pro-Ala-Gly-Pro-NHMe、Ac-Ala-Gly-Pro-Ala-Glc-Pro-NHMe和Ac-Ala-Glc-Pro-Ala-Gly-Pro-NHMe，其中Glc代表乙醇酸。描述了这些化合物在氘代二甲亚砜和三氟乙醇中的1H-核磁共振特性。在氘代二甲亚砜中，这些化合物呈无规状态，而在三氟乙醇中，甘氨酸酰胺质子似乎比其他酰胺质子更少暴露于溶剂中。这三种化合物的行为几乎没有差异。
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