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P200潜伏期缩短与牵连观念:精神分裂症认知易感性的听觉诱发电位指标?

Reduced P200 latency and allusive thinking: an auditory evoked potential index of a cognitive predisposition to schizophrenia?

作者信息

Catts S V, Armstrong M S, Ward P B, McConaghy N

出版信息

Int J Neurosci. 1986 Sep;30(3):173-9. doi: 10.3109/00207458608985668.

DOI:10.3109/00207458608985668
PMID:3759348
Abstract

Auditory evoked potentials were recorded in healthy medical students who were grouped according to whether they obtained a high or low score on an Object Sorting Test (OST), on which schizophrenics also obtain high scores. High-OST scoring male students compared to Low-OST scoring male students showed reduced P200 latency. This finding was replicated in a second study of medical students. The authors believe these results support the hypothesis that schizophrenic thought disorder and an equivalent loosening of thinking in nonschizophrenic populations (allusive thinking) have a neurophysiological basis in common, namely a relative weakness of inhibition operating on cortical and subcortical structures.

摘要

对健康医学生进行听觉诱发电位记录,这些学生根据在物体分类测试(OST)中得分高低分组,精神分裂症患者在该测试中也会获得高分。与低分OST的男学生相比,高分OST的男学生P200潜伏期缩短。这一发现于对医学生的第二项研究中得到重复。作者认为,这些结果支持以下假设:精神分裂症的思维障碍以及非精神分裂症人群中类似的思维松散(牵连观念性思维)具有共同的神经生理基础,即在皮层和皮层下结构上起作用的抑制相对减弱。

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