梗阻性肾病肾间质纤维化机制的研究进展

Wang Kangning, Liao Qiuling, Chen Xiang

Department of Urology Surgery, Xiangya Hospital Central South University, Changsha City, Hunan Province, 410008, China.

Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha City, Hunan Province, 410011, China.

Heliyon. 2023 Jul 27;9(8):e18723. doi: 10.1016/j.heliyon.2023.e18723. eCollection 2023 Aug.

Renal fibrosis is a common result for various chronic kidney diseases developing to the end stage. It is a pathological process characterized by the destruction of normal kidney structure and the subsequent replacement with fibrous tissue, which primarily involves fibroblast proliferation and extracellular matrix deposition. Obstruction is a common cause of renal fibrosis, and obstructive renal fibrosis is a common disease in urology. Obstructive renal fibrosis, characterized by its insidious onset, is the result of a complex interplay of multiple factors. These factors encompass renal tubular epithelial cell injury, the presence of a hypoxic microenvironment in affected kidney tissue, inflammatory cell infiltration, release of inflammatory mediators, and the release of renal fibrosis growth factors, among others. This paper reviews the research progress on the mechanism and treatment of renal interstitial fibrosis.

肾纤维化是各种慢性肾脏疾病发展至终末期的常见结果。它是一种病理过程，其特征是正常肾脏结构遭到破坏，随后被纤维组织取代，主要涉及成纤维细胞增殖和细胞外基质沉积。梗阻是肾纤维化的常见原因，梗阻性肾纤维化是泌尿外科的一种常见疾病。梗阻性肾纤维化起病隐匿，是多种因素复杂相互作用的结果。这些因素包括肾小管上皮细胞损伤、受累肾组织中缺氧微环境的存在、炎性细胞浸润、炎性介质释放以及肾纤维化生长因子释放等。本文综述了肾间质纤维化的机制及治疗研究进展。