Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, China.
Adv Clin Exp Med. 2024 May;33(5):463-471. doi: 10.17219/acem/169795.
Total cholesterol (TC) levels represent the comprehensive level of human cholesterol metabolism, which is closely related to the nutritional status, metabolic level, disease development, and aging of the human body. Total cholesterol plays an important role in the maintenance of bodily functions, regulation of sexual function, immune regulation, and in the development of organisms. Abnormal TC levels are an important risk factor for cardiovascular disease (CVD), and TC is closely related to the development of many diseases, and is used as an important indicator of human blood lipid levels and overall health status. However, the relationship between serum TC levels and the prognosis of patients with hip fractures remains unclear.
To evaluate the association between TC levels and all-cause mortality in patients with geriatric hip fractures.
Elderly patients with hip fractures were screened between January 2015 and September 2019. Patient demographic and clinical characteristics were recorded. Linear multivariate Cox regression models were used to identify the association between TC levels and all-cause mortality. Analyses were performed using Empower Stats and R software.
Three hundred and thirty-nine patients were enrolled. The mean follow-up period was 34.18 months. There were 99 (29.20%) cases of all-cause mortality. Total cholesterol levels after hip fracture were linearly associated with all-cause mortality in the elderly. Linear multivariate Cox regression models showed that TC levels were associated with mortality (hazard ratio (HR) = 0.67; 95% confidence interval (95% CI): 0.53-0.85; p = 0.001 after adjusting for confounding factors). Each 1 mmol/L increase in TC levels was associated with a 33% reduction in morbidity and mortality. Compared with the low-TC group, mortality was significantly lower in the middle-TC group (HR = 0.58; 95% CI: 0.35-0.94; p = 0.027) and high-TC group (HR = 0.45; 95% CI: 0.27-0.75; p = 0.002).
Total cholesterol levels were associated with mortality in geriatric hip fracture patients and could be considered a protective factor for all-cause mortality.
总胆固醇（TC）水平代表人体胆固醇代谢的综合水平，与人体的营养状况、代谢水平、疾病发展和衰老密切相关。总胆固醇在维持身体功能、调节性功能、免疫调节和生物发育中起着重要作用。TC 水平异常是心血管疾病（CVD）的重要危险因素，TC 与许多疾病的发展密切相关，是反映人体血脂水平和整体健康状况的重要指标。然而，血清 TC 水平与髋部骨折患者预后的关系尚不清楚。
评估老年髋部骨折患者 TC 水平与全因死亡率的关系。
筛选 2015 年 1 月至 2019 年 9 月间的老年髋部骨折患者。记录患者的人口统计学和临床特征。采用线性多变量 Cox 回归模型来确定 TC 水平与全因死亡率之间的关系。使用 EmpowerStats 和 R 软件进行分析。
共纳入 339 例患者。平均随访时间为 34.18 个月。有 99 例（29.20%）发生全因死亡。髋部骨折后 TC 水平与老年人的全因死亡率呈线性相关。线性多变量 Cox 回归模型显示，TC 水平与死亡率相关（危险比（HR）=0.67；95%置信区间（95%CI）：0.53-0.85；p=0.001，在调整混杂因素后）。TC 水平每增加 1mmol/L，发病率和死亡率降低 33%。与低 TC 组相比，中 TC 组（HR=0.58；95%CI：0.35-0.94；p=0.027）和高 TC 组（HR=0.45；95%CI：0.27-0.75；p=0.002）的死亡率显著降低。
TC 水平与老年髋部骨折患者的死亡率相关，可作为全因死亡率的保护因素。
