Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.
Oncol Rep. 2023 Oct;50(4). doi: 10.3892/or.2023.8613. Epub 2023 Aug 18.
The ubiquitin‑proteasome system is a major degradation pathway for >80% of proteins . Deubiquitylases, which remove ubiquitinated tags to stabilize substrate proteins, are important components involved in regulating the degradation of ubiquitinated proteins. In addition, they serve multiple roles in tumor development by participating in physiological processes such as protein metabolism, cell cycle regulation, DNA damage repair and gene transcription. The present review systematically summarized the role of ubiquitin‑specific protease 2 (USP2) in malignant tumors and the specific molecular mechanisms underlying the involvement of in tumor‑associated pathways. reverses ubiquitin‑mediated degradation of proteins and is involved in aberrant proliferation, migration, invasion, apoptosis and drug resistance of tumors. Additionally, the present review summarized studies reporting on the use of as a therapeutic target for malignancies such as breast, liver, ovarian, colorectal, bladder and prostate cancers and glioblastoma and highlights the current status of pharmacological research on . The clinical significance of as a therapeutic target for malignant tumors warrants further investigation.
泛素-蛋白酶体系统是 >80%的蛋白质的主要降解途径。去泛素化酶通过去除泛素化标签来稳定底物蛋白，是参与调节泛素化蛋白降解的重要组成部分。此外，它们通过参与蛋白质代谢、细胞周期调控、DNA 损伤修复和基因转录等生理过程，在肿瘤发生发展中发挥多种作用。本综述系统总结了泛素特异性蛋白酶 2 (USP2) 在恶性肿瘤中的作用及其在肿瘤相关途径中参与的具体分子机制。USP2 逆转了泛素介导的蛋白质降解，并参与肿瘤的异常增殖、迁移、侵袭、凋亡和耐药。此外，本综述还总结了将 USP2 作为乳腺癌、肝癌、卵巢癌、结直肠癌、膀胱癌、前列腺癌和胶质母细胞瘤等恶性肿瘤的治疗靶点的研究报告，并强调了 USP2 药理学研究的现状。USP2 作为恶性肿瘤治疗靶点的临床意义值得进一步研究。
