Di Mascio R, Beghi E, Sasanelli F, Tognoni G
Ital J Neurol Sci. 1986 Aug;7(4):421-9. doi: 10.1007/BF02283020.
A multicenter prospective investigation was conducted in 17 teaching and general hospitals in Italy to assess the efficacy of the care delivered to previously untreated patients with epilepsy. 175 cases were included and allocated to monotherapy. Only 112 cases completed the first year of follow-up. Of these, 59 (52.7%) were completely controlled and 53 (47.3%) had one or more seizure relapses. Controlled and uncontrolled patients were compared with respect to the main variables believed to influence non-responsiveness to standard therapy. The proportion of cases with relapses was significantly associated with the number of seizures reported before treatment was started. Selected seizure patterns (absences, myoclonic seizures) and prolonged disease duration were also reported more frequently among patients with recurrences. The implications of these findings are discussed with respect to drug response and prognosis of epilepsy.
在意大利的17家教学医院和综合医院开展了一项多中心前瞻性调查，以评估给予既往未接受治疗的癫痫患者的护理效果。纳入175例患者并分配接受单一疗法治疗。只有112例患者完成了第一年的随访。其中，59例（52.7%）完全得到控制，53例（47.3%）有一次或多次癫痫复发。就被认为会影响对标准治疗无反应性的主要变量而言，对得到控制和未得到控制的患者进行了比较。复发病例的比例与开始治疗前报告的癫痫发作次数显著相关。在复发患者中，特定的癫痫发作类型（失神发作、肌阵挛发作）和病程延长也更为常见。针对这些发现对癫痫药物反应和预后方面的意义进行了讨论。
