Martín Javier Murillo, Revelles Juan Maria, Aznar Nerea Martínez, Jiménez Lidia Maroñas, Orellana Jose Barbosa, Gomariz Miguel Ángel, Alfertshofer Michael, Cotofana Sebastian
CM Clinic, Palma de Mallorca, Spain.
Clínica Le Boost, Madrid, Spain.
J Cosmet Dermatol. 2023 Nov;22(11):2940-2949. doi: 10.1111/jocd.15795. Epub 2023 Aug 18.
Various injection algorithms have been proposed in the past which are in line with the three aesthetic principles: upper face first, lateral face first, and deep regions first. However, increasing evidence is provided that the upper midface can be targeted with superficial soft tissue filler injections alone too.
To investigate in a prospective split-face study design whether superficial or deep upper midfacial injections provide superior aesthetic outcomes.
A total of n = 20 study participants (100% females; age 43.95 (11.7) years; BMI 22.92 (2.6) kg/m ) were treated with superficial soft tissue filler injections on side of their face and deep injections on the contralateral side with a mean volume of 0.78 cc. Outcome was evaluated at 7 weeks follow-up for midfacial, and lower facial volume, for medial and lateral facial skin vector displacement, and for improvement of nasolabial, crow's feet, and upper cheek fullness severity scores.
No adverse events related to safety or product tolerability were observed during the entire study period. All semiquantitative scores improved statistically significantly after the observational period (p < 0.001) but displayed no difference between the two applied injection techniques (p > 0.05).
The results of this split-face study revealed that both the superficial and the deep cannula injection technique for midface volumization statistically significantly improve the midfacial volume, reduce nasolabial fold and crow's feet severity. No statistically significant difference was observed between the two injection techniques when compared via semiquantitative and objective outcome evaluation after 7 weeks follow-up.
过去已经提出了各种注射算法，这些算法符合三条美学原则：先上脸、先侧脸、先深部区域。然而，越来越多的证据表明，单独使用浅表软组织填充剂注射也可以针对面中部上半部分。
在前瞻性半脸研究设计中，研究浅表或深部面中部上半部分注射是否能提供更好的美学效果。
共有n = 20名研究参与者（100%为女性；年龄43.95（11.7）岁；体重指数22.92（2.6）kg/m²），一侧面部接受浅表软组织填充剂注射，对侧接受深部注射，平均注射量为0.78 cc。在随访7周时评估面中部和下部面部体积、面部内侧和外侧皮肤向量位移以及鼻唇沟、鱼尾纹和上脸颊饱满度严重程度评分的改善情况。
在整个研究期间未观察到与安全性或产品耐受性相关的不良事件。观察期后，所有半定量评分均有统计学显著改善（p < 0.001），但两种注射技术之间无差异（p > 0.05）。
这项半脸研究的结果表明，用于面中部容积增加的浅表和深部套管注射技术在统计学上均能显著改善面中部体积，降低鼻唇沟和鱼尾纹的严重程度。随访7周后，通过半定量和客观结果评估比较，两种注射技术之间未观察到统计学显著差异。
