Department of Dermatology and Venereology, Centro Hospitalar Universitário de São João, Porto, Portugal.
Department of Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal.
Eur J Dermatol. 2023 Jun 1;33(3):241-244. doi: 10.1684/ejd.2023.4478.
Hidradenocarcinoma is a rare malignant sweat gland tumour, characterized by a slow but aggressive course, with high rates of local recurrence and metastasis. Due to its rarity, histological criteria and therapeutic guidelines are poorly defined, posing a major challenge for clinicians and pathologists.
To present two new cases of metastatic hidradenocarcinoma as well as a review of the literature.
MATERIALS & METHODS: We describe two case studies and a review of the literature based on a search using the MEDLINE (PubMed) electronic database.
The first patient was a 61-year-old woman with a perimamillary hidradenocarcinoma that arose from the malignant transformation of a benign childhood lesion and developed regional lymph node metastases after wide excision and adjuvant radiotherapy. The second patient was a 63-year-old man who developed cutaneous and renal metastases several years after the complete excision of a lumbar hidradenocarcinoma. As far as we can ascertain, kidney metastasis from hidradenocarcinoma has not previously been described.
Most authors recommend wide excision as the treatment of choice for hidradenocarcinoma, however, optimal adjuvant therapy remains to be determined. Our cases add to the limited knowledge available, but high-quality studies to find new effective treatments are needed.
大汗腺癌是一种罕见的恶性汗腺肿瘤，其特点是病程缓慢但具有侵袭性，局部复发和转移率高。由于其罕见性，组织学标准和治疗指南定义不明确，这对临床医生和病理学家构成了重大挑战。
介绍两例转移性大汗腺癌病例，并进行文献复习。
我们描述了两例病例，并结合 MEDLINE（PubMed）电子数据库进行了文献复习。
第一例患者为 61 岁女性，发生于鼻翼旁的大汗腺癌，起源于儿童时期良性病变的恶性转化，在广泛切除和辅助放疗后发生区域淋巴结转移。第二例患者为 63 岁男性，在完全切除腰背部大汗腺癌数年后发生皮肤和肾脏转移。据我们所知，大汗腺癌转移至肾脏尚未有报道。
大多数作者建议广泛切除作为大汗腺癌的首选治疗方法，但最佳辅助治疗仍有待确定。我们的病例增加了有限的知识，但需要高质量的研究来寻找新的有效治疗方法。
