Toll 样受体 4：多种人类疾病的潜在治疗靶点。
Toll-like receptor 4: A potential therapeutic target for multiple human diseases.
机构信息
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China.
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China.
出版信息
Biomed Pharmacother. 2023 Oct;166:115338. doi: 10.1016/j.biopha.2023.115338. Epub 2023 Aug 16.
The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various diseases, encompassing cardiovascular disorders, neoplastic conditions, and inflammatory ailments. This comprehensive review centers on elucidating the architectural and distributive characteristics of TLR4, its conventional signaling pathways, and its mode of action in diverse disease contexts. Ultimately, this review aims to propose novel avenues and therapeutic targets for clinical intervention.
免疫反应在疾病发病机制中起着关键作用。Toll 样受体 4（TLR4）作为一种固有免疫受体，在体内广泛表达，其失调显著导致多种疾病的发生，包括心血管疾病、肿瘤疾病和炎症性疾病。本综述重点阐述 TLR4 的结构和分布特征、其常规信号通路以及在不同疾病环境中的作用方式。最终，本综述旨在为临床干预提出新的途径和治疗靶点。
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