Zhang Jiang, Zhang Jingyue, Sun Hui, Yang Jia, Ma Yingzi, Chen Kexuan, Su Jing, Yu Xiaohui, Yang Futing, Zhang Zhiwei, Zhao Tianyu, Hu Xiuying, Zhai Yiran, Liu Qihong, Wang Jiaojian, Liu Chunyan, Wang Zhengbo
College of Electrical Engineering, Sichuan University, Chengdu, China; Med-X Center for Informatics, Sichuan University, Chengdu, China.
College of Electrical Engineering, Sichuan University, Chengdu, China.
Sleep Med. 2023 Oct;110:172-178. doi: 10.1016/j.sleep.2023.08.014. Epub 2023 Aug 16.
Restless legs syndrome (RLS) has serious effects on patients' sleep quality, physical and mental health. However, the pathophysiological mechanisms of RLS remain unclear. This study utilized both static and dynamic functional activity and connectivity analyses approaches as well as effective connectivity analysis to reveal the neurophysiological basis of RLS.
The resting-state functional MRI (rs-fMRI) data from 32 patients with RLS and 33 age-, and gender-matched healthy control (HC) were collected. Dynamic and static amplitude of low frequency fluctuation (ALFF), functional connectivity (FC), and Granger causality analysis (GCA) were employed to reveal the abnormal functional activities and couplings in patients with RLS.
RLS patients showed over-activities in left parahippocampus and right cerebellum, hyper-connectivities of right cerebellum with left basal ganglia, left postcentral gyrus and right precentral gyrus, and enhanced effective connectivity from right cerebellum to left postcentral gyrus compared to HC.
Abnormal cerebellum-basal ganglia-sensorimotor cortex circuit may be the underlying neuropathological basis of RLS. Our findings highlight the important role of right cerebellum in the onset of RLS and suggest right cerebellum may be a potential target for precision therapy.
不安腿综合征（RLS）对患者的睡眠质量、身心健康有严重影响。然而，RLS的病理生理机制仍不清楚。本研究采用静态和动态功能活动及连接性分析方法以及有效连接性分析来揭示RLS的神经生理基础。
收集了32例RLS患者和33例年龄、性别匹配的健康对照（HC）的静息态功能磁共振成像（rs-fMRI）数据。采用动态和静态低频波动幅度（ALFF）、功能连接性（FC）和格兰杰因果分析（GCA）来揭示RLS患者的异常功能活动和耦合。
与HC相比，RLS患者左侧海马旁回和右侧小脑活动增强，右侧小脑与左侧基底神经节、左侧中央后回和右侧中央前回的连接性增强，且从右侧小脑到左侧中央后回的有效连接性增强。
小脑-基底神经节-感觉运动皮层回路异常可能是RLS潜在的神经病理学基础。我们的研究结果突出了右侧小脑在RLS发病中的重要作用，并表明右侧小脑可能是精准治疗的潜在靶点。
