School of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China; Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
J Hazard Mater. 2023 Oct 5;459:132290. doi: 10.1016/j.jhazmat.2023.132290. Epub 2023 Aug 13.
Ambient ozone (O) pollution has been associated with an increased risk of cardiovascular diseases. However, few studies have addressed the effect of O exposure on electrocardiogram (ECG) abnormalities, a subclinical indicator of early damage to the cardiovascular system. This study aimed to examine the association between short-term exposure to O and ECG abnormalities. We included 102,027 visits of 47,290 participants over 40 years old who had a normal ECG at baseline and then visited again at least once from the China National Stroke Screening Survey (CNSSS). Short-term ozone exposure concentrations were measured as averages of maximum daily 8-h O concentrations over the two weeks prior to ECG measurements. The generalized estimation equations models were used to evaluate the association between O exposure and ECG abnormalities. For every 10 µg/m increment in short-term O concentration, the odds ratio of any ECG abnormality was 1.055 (95% confidence interval [CI] 1.045-1.064). For ECG-diagnosed cardiac arrhythmia, the odds ratio was 1.062 (95% CI 1.052-1.072). A nonlinear analysis showed a sublinear relationship between O exposure and risk for ECG abnormalities. The association between O exposure and ECG abnormalities varied by subpopulation. Our study provided new epidemiological evidence on the association between short-term O exposure and ECG abnormalities. There is an urgent need to control ambient O pollution to prevent cardiovascular events.
环境臭氧（O）污染与心血管疾病风险增加有关。然而，很少有研究探讨 O 暴露对心电图（ECG）异常的影响，ECG 异常是心血管系统早期损伤的亚临床指标。本研究旨在研究短期 O 暴露与 ECG 异常之间的关联。我们纳入了中国国家卒中筛查调查（CNSSS）中 47290 名 40 岁以上参与者的 102027 次就诊，这些参与者在基线时心电图正常，随后至少再次就诊一次。短期臭氧暴露浓度以 ECG 测量前两周内每日 8 小时最大臭氧浓度的平均值来衡量。广义估计方程模型用于评估 O 暴露与 ECG 异常之间的关联。短期 O 浓度每增加 10μg/m，任何 ECG 异常的比值比为 1.055（95%置信区间 1.045-1.064）。对于 ECG 诊断的心律失常，比值比为 1.062（95%置信区间 1.052-1.072）。非线性分析显示 O 暴露与 ECG 异常风险之间存在次线性关系。O 暴露与 ECG 异常之间的关联因亚人群而异。本研究为短期 O 暴露与 ECG 异常之间的关联提供了新的流行病学证据。迫切需要控制环境 O 污染以预防心血管事件。
