Lechartier Benoit, Kularatne Mithum, Jaïs Xavier, Humbert Marc, Montani David
Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Semin Respir Crit Care Med. 2023 Dec;44(6):721-727. doi: 10.1055/s-0043-1770115. Epub 2023 Aug 18.
Pulmonary hypertension (PH) is a pathophysiological manifestation of a heterogeneous group of diseases characterized by abnormally elevated pulmonary arterial pressures diagnosed on right heart catheterization. The 2022 European Society of Cardiology (ESC) and European Respiratory Society (ERS) Guidelines for the diagnosis and treatment of PH provides a new hemodynamic definition to define PH by lowering the threshold of the mean pulmonary artery pressure (mPAP) to 20 mm Hg. Precapillary PH is thus now defined as a mPAP >20 mm Hg together with a normal pulmonary artery wedge pressure (<15 mm Hg) and an increased pulmonary vascular resistance (>2 Wood Units). The ESC/ERS 2022 Guidelines also introduce a revised clinical classification of PH while retaining its previous distinction between the five groups according to the underlying pathophysiology.
肺动脉高压（PH）是一组异质性疾病的病理生理表现，其特征为通过右心导管检查诊断出肺动脉压力异常升高。2022年欧洲心脏病学会（ESC）和欧洲呼吸学会（ERS）的肺动脉高压诊断和治疗指南提供了新的血流动力学定义，将肺动脉平均压（mPAP）阈值降至20 mmHg来定义肺动脉高压。因此，目前毛细血管前性肺动脉高压的定义为mPAP>20 mmHg，同时肺动脉楔压正常（<15 mmHg）且肺血管阻力增加（>2 Wood单位）。ESC/ERS 2022指南还引入了修订后的肺动脉高压临床分类，同时保留了先前根据潜在病理生理学在五组之间的区分。
