Journée Sarah H, Mathis Victor P, Fillinger Clémentine, Veinante Pierre, Yalcin Ipek
Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France; Department of Psychiatry and Neuroscience, Université Laval, Québec, QC G1V 0A6, Canada.
Neurosci Biobehav Rev. 2023 Oct;153:105362. doi: 10.1016/j.neubiorev.2023.105362. Epub 2023 Aug 16.
Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex (ACC) as a site of interest for several neurological and psychiatric conditions. The ACC plays a critical role in emotion, autonomic regulation, pain processing, attention, memory and decision making. An increasing number of studies have demonstrated the involvement of the ACC in the emotional component of pain and its comorbidity with emotional disorders such as anxiety and depression. Thanks to the development of animal models combined with state-of-the-art technologies, we now have a better mechanistic understanding of the functions of the ACC. Hence, the primary aim of this review is to compile the most recent preclinical studies on the role of ACC in the emotional component and consequences of chronic pain. Herein, we thus thoroughly describe the pain-induced electrophysiological, molecular and anatomical alterations in the ACC and in its related circuits. Finally, we discuss the next steps that are needed to strengthen our understanding of the involvement of the ACC in emotional and pain processing.
在过去20年中，临床和临床前研究表明，前扣带回皮质（ACC）是多种神经和精神疾病的一个重要部位。ACC在情绪、自主调节、疼痛处理、注意力、记忆和决策中起着关键作用。越来越多的研究表明，ACC参与疼痛的情绪成分及其与焦虑和抑郁等情绪障碍的共病。由于结合了先进技术的动物模型的发展，我们现在对ACC的功能有了更好的机制理解。因此，本综述的主要目的是汇编关于ACC在慢性疼痛的情绪成分和后果中作用的最新临床前研究。在此，我们全面描述了ACC及其相关回路中疼痛诱导的电生理、分子和解剖学改变。最后，我们讨论了加强我们对ACC参与情绪和疼痛处理理解所需的下一步措施。
